Uso de secnidazol y homeopatía para el control de giardiasis en perros

Use of secnidazole and homeopathy for giardiasis control in dogs

Los perros con infecciones por Giardia tienen diarrea que persiste durante días, incluso después del tratamiento. Manejamos la giardiasis canina usando dos enfoques distintos: tratamiento con el secnidazol antiprotozoario solo; y secnidazol más un producto homeopático indicado para el control de la diarrea en perros. Tratamiento I: Diez perros beagle mostraron signos clínicos de diarrea severa. Sus heces revelaron una gran cantidad de quistes compatibles con Giardia sp. Por lo tanto, tratamos a los perros con secnidazol (10 mg/kg, dosis única) por vía oral. Cinco días después del tratamiento, todos los perros fueron negativos para Giardia spp. Tratamiento II: Tres meses después, los mismos diez Beagles nuevamente presentaron diarrea. Se recogieron las heces, revelando Giardia sp. en todos los perros. Esta vez, los tratamos con un antiprotozoo (secnidazol, dosis de 10 mg/kg) combinado con un medicamento homeopático comercial para el control de la diarrea (dosis de 3 g/animal a intervalos de 12 h). Descubrimos que se necesitaban de tres a cinco dosis homeopáticas para lograr puntajes fecales normales en todos los perros. Después de 5 días de tratamiento, las muestras de heces tuvieron una consistencia normal y fueron negativas para Giardia. Este es el primer registro de uso de secnidazol para el control de la giardiasis canina. asociado con homeopáticos en la evitación de diarrea.

1. Thompson RCA, Monis PT. Variation in Giardia: implications for taxonomy and epidemiology. Adv Parasitol. 2014; 58:69-137. https://doi.org/10.1016/S0065-308X(04)58002-8.
2. Hooshyar H, Rostamkhani P, Delavari M. Giardia lamblia infection: review of current diagnostic strategies. Gastroenterol. Hepatol Bed Bench. 2019; 12:3–12. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441489/#__ffn_sectitle
3. Olson ME, O’Handley RM, Ralston BJ, Mcallister TA, Thompson RCA. Update on Cryptosporidium and Giardia infections in cattle. Trends Parasitol. 2014; 20:185-191. https://doi.org/10.1016/j.pt.2004.01.015.
4. Bahr SE, Morais HA. Pessoas imunocomprometidas e animais de estimação. Rev Clin Vet. 2011; 30:17-22. https://www.researchgate.net/publication/316282703_Pessoas_imunocomprometidas_e_animais_de_estimacao
5. Gomes KB, Fernandes AP, Menezes A, Amorim JR, Silva EF, Rocha MO. Giardia duodenalis: genotypic comparison between a human and a canine isolates. Rev Soc Bras Med Trop. 2011; 44:508-510. https://doi.org/10.1590/S0037-86822011000400021
6. Rinaldi L, Maurelli MP, Musella V, Veneziano V, Carbone S, Di Sarno A, Paone M, Ciringoli G. Giardia and Cryptosporidium in canine fecal samples contaminating an urban area. Res Vet Sci. 2017; 84:413-415. https://doi.org/10.1016/j.rvsc.2007.05.006.
7. Ruiz JD, Ramírez GP, Múnera AM, Arroyave C, Castaño L, López P. Comparison of secnidazole and fenbendazole for the treatment of asymptomatic Giardia infection in dogs. Vet Sci Res. 2019; 1: 24-28. https://doi.org/10.30564/vsr.v1i1.1067
8. Robertson ID, Irwin PJ, Lymbery AJ, Thompson RCA. The role of companion animals in the emergence of parasitic zoonoses. Int J Parasitol. 2010; 30:1369-1377. https://doi.org/ 10.1016/s0020-7519(00)00134-x.
9. Da Silva AS, Castro VSP, Tonin AA, Brendler S, Costa MM, Jaques JA, Bertoletti B, Zanette RA, Raiser AG, Mazzanti CM, Lopes ST, Monteiro SG. Secnidazole for the treatment of giardiasis in naturally infected cats. Int Parasitol. 2011; 60:429-432. http://dx.doi.org/10.1016/j.parint.2011.06.024.
10. Volpato A, Fortuoso BF, Campigotto G, Glombowsky P, Botarri NB, Lopes LS, Da Silva AS. Secnidazole for control of giardiasis in dairy calves. Exp Parasitol. 2018; 189:16-18. https://doi.org/10.1016/j.exppara.2018.04.008.
11. Rossignol JF, Maisonneuve H, Cho YW. Nitroimidazoles in the treatment of trichomoniasis, giardiasis, and amebiasis. Int J Clin Pharmacol Ther Toxicol. 1984; 22(2):63-72. https://pubmed.ncbi.nlm.nih.gov/6698665/
12. Teixeira MZ. Therapeutic use of the rebound effect of modern drugs: “New homeopathic medicines”. Rev Assoc Med Bras. 2017; 63:100-108. https://doi.org/10.1590/1806-9282.63.02.100
13. Charles K, Rizzardi R, Oliveira BF, Silva CM, Martins LP, Fantini CC. Homeopathic complex in the prevention and treatment of diarrhea in suckling piglets. Rev Bras Saúde Prod Anim. 2012; 13:74-82. http://dx.doi.org/10.1590/S1519-99402012000100007.
14. Fortuoso BF, Volpato A, Rampazzo L, Glombowsky P, Griss LG, Galli GM, Stefani LM, Baldissera MD, Ferreira EB, Machado G, Da Silva AS. Homeopathic treatment as an alternative prophylactic to minimize bacterial infections and prevent neonatal diarrhea in calves. Microb Pathog. 2018; 114:95-98. http://dx.doi.org/10.1016/j.micpath.2017.11.041.
15. Fortuoso BF, Gebert RR, Griss LG, Glombovisky P, Cazarotto CJ, Rampazzo L, Stefani LM, Ferreira EB, Da Silva AS. Reduction of stool bacterial counts and prevention of diarrhea using an oral homeopathic product in newborn lambs. Microb Pathog. 2018; 127:347-351. http://dx.doi.org/10.1016/j.micpath.2018.12.022.
16. Gressler LT, Silva AS, Silva MK, Tonin AA, Monteiro SG. Gastrointestinal parasites of cavy (Cavia aperea aperea) in southern Brazil. Res Vet Sci 2010; 89(2):206-208. https://doi.org/10.1016/j.rvsc.2010.02.012
17. Feldman, BF, Zinkl JG, Jain NC. Schalm’s Veterinary Hematology. Philadelphia, 5th ed., 2000.
18. Di Prisco MC, Jiménez JC, Rodríguez N, Costa V, Villamizar J, Silvera A, Carrillo M, Lira C, Zerpa E, Lopez Y. Clinical trial with Secnidazole in a single dose in Venezuelan children infected by Giardia intestinalis. Invest Clin. 2010; 41:179–88. https://www.ncbi.nlm.nih.gov/pubmed/11029834
19. Escobedo AA, Canþete R, Gonzalez ME, Pareja A, Cimerman S, Almirall P. A randomized trial comparing mebendazole and secnidazol for the treatment of giardiasis. Ann Trop Med Parasitol. 2013; 97:499–504. http://dx.doi.org/10.1179/000349803235002380.
20. Ural K, Gultekin M, Pasa S, Aysul N, Ayan A. Chloroquine treatment against naturally occurring Giardia duodenalis infection in dogs. Med Weter. 2017; 73:280-283. https://doi.org/10.21521/mw.5695.
21. Modarresi, A. Comparing the effect of secnidazole and metronidazole for the treatment of giardiasis in children. Pediatr Res. 2011; 70:470. https://doi.org/10.1038/pr.2011.695
22. Solaymani-Mohammadi S1, Genkinger JM, Loffredo CA, Singer SM. A meta-analysis of the effectiveness of albendazole compared with metronidazole as treatments for infections with Giardia duodenalis. PLoS Negl Trop Dis. 2010: 11:e682. https://doi.org/10.1371/journal.pntd.0000682
23. Santos FAG, Yamamura MH, Vidotto O, Camargo PL. Occurrence of gastrointestinal parasites in dogs (Canis familiaris) with acute diarrhea from metropolitan region of Londrina, Parana State, Brazil. Semina: Ciên Agra. 2017; 28:257-268. http://dx.doi.org/10.5433/1679-0359.2007v28n2p257.
24. Allain T, Amat CB, Motta JP, Manko A, Buret AG. Interactions of Giardia sp. with the intestinal barrier: Epithelium, mucus, and microbiota. Tissue Barriers 2017; 5:e1274354. http://dx.doi.org/10.1080/21688370.2016.1274354
25. Cucherat M, Haugh MC, Gooch M, Boissel JP. Evidence of clinical efficacy of homeopathy: a meta-analysis of clinical trials. Eur J Clin Pharmacol. 2010; 56:27-33. http://dx.doi.org/10.1007/s002280050716.
26. Karahalli C, Ural K. Single dose secnidazol treatment efficacy against naturally occurring Giardia duodenalis infection in dogs. Magyar Allatorvosok Lapja .2017; 139: 621-630. https://univet.hu/files/subpages/153/files/MAL-2017-10_content.pdf