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AutoresG. Andres Contreras B Walter M. Guterbock Juan Muñoz R Phillip M. Sears
Objective. To compare four different dry cow treatments (DCT) and establish their effectiveness in reducing intramammary infections (IIM). Materials and methods. DCTs included systemic tylosin (12g) alone or accompanied by cefapirine intramammary infusions and or an internal teat sealant. A total number of 278 cows at the end of lactation period were randomly assigned to one of 4 dry cow treatment groups: CESE Group (n=89), intramammary cephapirin and teat sealant. TYCESE Group (n=84), intramammary cephapirin, tylosin 12 g intramuscular and teat sealant. TYSE Group (n=86), 12 g intramuscular tylosin and teat sealant; TY Group (n=76) 12 g intramuscular tylosin only. Milk samples for culture were collected at dry-off and 1 and 2 weeks after calving. Somatic cell counts (SCC) were taken from Dairy Herd Improvement Association (DHI) tests at dry-off, and the first two test days after calving. Results. Bacteria cure rate for Gram-positive intramammary infections (IMI) for TYCESE group was 93.6%, CESE group 78.9%, TYSE group 88.2%, and TY group 78.1%. All four groups showed a decrease in the SCC upon the first and second test after calving. Conclusions. The use of systemic tylosin in combination with intramammary antibiotics increased DCT effectiveness improving the Gram-positive cure rate IMI. Furthermore, systemic tylosin alone plus teat sealant is as effective as cephapirin plus teat sealant when used as DCT.
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2. Zwald AG, Ruegg PL, Kaneene JB, Warnick LD, Wells SJ, Fossler C, et al. Management Practices and Reported Antimicrobial Usage on Conventional and Organic Dairy Farms. J Dairy Sci 2004; 87(1):191-201. http://dx.doi.org/10.3168/jds.S0022-0302(04)73158-6
3. Robert A, Seegers H, Bereille N. Incidence of intramammary infections during the dry period without or with antibiotic treatment in dairy cows - a quantitative analysis of published data. Vet Res 2006; 37:25-48. http://dx.doi.org/10.1051/vetres:2005047
4. Nickerson SC, Owens WE, Fox LK, Scheifinger CC, Shryock TR, Spike TE. Comparison of Tilmicosin and Cephapirin as Therapeutics for Staphylococcus aureus Mastitis at Dryoff. J Dairy Sci 1999; 82(4):696-703. http://dx.doi.org/10.3168/jds.S0022-0302(99)75286-0
5. Erskine RJ, Bartlett PC, Crawshaw PC, Gombas DM. Efficacy of Intramuscular Oxytetracycline as a Dry Cow Treatment for Staphylococcus aureus Mastitis. J Dairy Sci 1994; 77(11):3347-3353. http://dx.doi.org/10.3168/jds.S0022-0302(94)77276-3
6. Bolourchi M, Hovareshti P, Tabatabayi AH. Comparison of the effects of local and systemic dry cow therapy for staphylococcal mastitis control. Prev Vet Med 1995; 25(1):63-67. http://dx.doi.org/10.1016/0167-5877(95)00508-0
7. Omura S. Macrolide antibiotics. Macrolide antibiotics, chemistry, biology and practice 1ed. Orlando: Academic press; 1984.
8. Riviere J. Comparative pharmacokinetics: principles, techniques, and applications. Ames: Iowa State University Press; 1999.
9. Hogan J, Gonzalez R, Harmon R, Nickerson SC, Oliver S, Pankey J. Laboratory Handbook on Bovine Mastitis. 1st ed. Madison, WI: The National Mastitis Council, Inc; 1999.
10. Sears PM, Smith BS, English PB, Herer PS, Gonzalez RN. Shedding Pattern of Staphylococcus aureus from Bovine Intramammary Infections. J Dairy Sci 1990; 73(10):2785-2789. http://dx.doi.org/10.3168/jds.S0022-0302(90)78964-3
11. McDougall S, Agnew KE, Cursons R, Hou XX, Compton CRW. Parenteral Treatment of Clinical Mastitis with Tylosin Base or Penethamate Hydriodide in Dairy Cattle. J Dairy Sci 2007; 90(2):779-789. http://dx.doi.org/10.3168/jds.S0022-0302(07)71562-X
12. Ziv G , Sulman F. Se rum and milk concentrations of spectinomycin and tylosin in cows and ewes. Am J Vet Res 1973; 34(3):329-333.
13. el-Sayed M, el-Attar H, Atef M, Yousif M. Pharmacokinetic profile of tylosin in mastitic cows. Dtsch Tierarztl Wochenschr 1986; 93(7):326-328.
14. Diarra MS, Malouin F, Jacques M. Postantibiotic and physiological effects of tilmicosin, tylosin, and apramycin at subminimal and suprainhibitory concentrations on some swine and bovine respiratory tract pathogens. Int J Antimicrob Agents 1999; 12(3):229-237. http://dx.doi.org/10.1016/S0924-8579(99)00069-2
15. Dingwell RT, Kel ton DF, Le slie KE . Management of the dry cow in control of peripartum disease and mastitis. Vet Clin North Am Food Anim Pract 2003; 19(1):235-265. http://dx.doi.org/10.1016/S0749-0720(02)00072-5
16. Berry EA, Hogeveen H, Hillerton JE. Decision tree analysis to evaluate dry cow strategies under UK conditions. J Dairy Res 2004; 71(04):409-418. http://dx.doi.org/10.1017/S0022029904000433
17. Huijps K, Hogeveen H. Stochastic Modeling to Determine the Economic Effects of Blanket, Selective, and No Dry Cow Therapy. J Dairy Sci 2007; 90(3):1225-1234. http://dx.doi.org/10.3168/jds.S0022-0302(07)71611-9