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Investigación de parámetros bioquímicos y perfil de citocinas en ovejas con ectima contagioso

Investigation of biochemical parameters and cytokine profile in sheep with contagious ecthyma inmunología del ectima infeccioso



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Polat-Dinçer, P. F., & Şahan, A. . (2024). Investigación de parámetros bioquímicos y perfil de citocinas en ovejas con ectima contagioso: inmunología del ectima infeccioso. Revista MVZ Córdoba, 27(s), e2581. https://doi.org/10.21897/rmvz.2581

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Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-CompartirIgual 4.0.

Pelin Fatoş Polat-Dinçer

Objetivo. El ectima contagioso es una enfermedad zoonótica mundial con una amplia gama de hospedadores y una alta morbilidad que causa graves pérdidas económicas.  Materiales y métodos. Se utilizaron 28 ovejas no vacunadas de 1 a 4 meses que presentaban síntomas clínicos de ectima y 10 ovejas sanas del mismo rango de edad. Se tomaron medidas de ALB, ALT, BUN, CHOL, CRE, GGT, GLU, TBIL y TP. Las costras obtenidas se homogeneizaron antes de realizar la extracción y PCR. Se usó ELISA para determinar los niveles de IL-2 e IL-4 en el suero animal positivo a PCR. Resultados. El análisis bioquímico reveló que los valores de ALT, BUN, GGT y CRE en los animales infectados fueron significativamente más altos que en el grupo de control (p = 0,000 yp = 0,001) mientras que los valores de TP y GLU fueron significativamente más bajos (p = 0,000). No hubo diferencias significativas en los valores de ALB, CHOL y TBIL (p = 0,1, p = 0,05, p = 0,08). En cuanto al perfil inmune, los animales infectados tenían niveles de IL-2 (28%) e IL-4 (60%) significativamente más altos que el grupo de control (p = 0,008 yp = 0,001). Conclusión. Los hallazgos indican que las citocinas Th1 (IL-2) y Th2 (IL-4) coexisten mientras que la respuesta de citocinas dominante en los animales infectados es Th2. Se cree que el resultado nos ayudará a comprender mejor la patogenia y las opciones de tratamiento de la enfermedad.


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