Efectos de amitraz más Parapoxvirus ovis sobre EGF, VEGF, IGF-1 e IGF-2 en la demodicosis generalizada canina

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Resumen

Objetivo. El propósito del estudio es investigar el efecto del tratamiento con amitraz más-Parapoxvirus ovis (IPPVO) sobre las concentraciones séricas y las expresiones cutáneas del factor de crecimiento insulínico (IGF) -1 y -2, factor de crecimiento epidérmico (EGF), vascular factor de crecimiento endotelial (VEGF), en perros que padecen demodicosis generalizada (GD). Materiales y métodos. A los perros afectados por GD se les inyectó 1 mL de IPPVO los días 0, 2 y 9 por vía subcutánea además del tratamiento con amitraz (0,025%) dos veces por semana durante 80 días. Las concentraciones de IGF-1, IGF-2, EGF y VEGF en suero sanguíneo se midieron mediante un kit de ensayo inmunoabsorbente ligado a enzimas específico para caninos. Las expresiones de EGF, VEGF, IGF-1 e IGF-2 en muestras de biopsia de piel se examinaron inmunohistoquímicamente. Resultados. Después del tratamiento de los perros con amitraz más-IPPVO en GD, demostramos una reducción significativa tanto en las concentraciones circulantes como en las expresiones cutáneas de EGF, VEGF, IGF-1 e IGF-2, que tienen un papel en la preservación de la integridad de la piel y la herida. curación. Conclusiones. Los resultados de este estudio sugieren que IGF-1, IGF-2 EGF y VEGF tienen un papel crucial en la progresión de la GD en perros. Se cree que los hallazgos de este estudio contribuirán al desarrollo de nuevas estrategias para el tratamiento de la GD, que es un problema de salud importante para los perros.

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Biografía del autor/a / Ver

Gul Fatma Yarim, Universidad Ondokuz Mayis, Turquía

Universidad Ondokuz Mayis, Facultad de Medicina Veterinaria, Departamento de Bioquímica, Samsun, Turkey.

Didem Pekmezci, Universidad Ondokuz Mayis, Turquía

Universidad Ondokuz Mayis, Facultad de Medicina Veterinaria, Departamento de Medicina Interna, Samsun, Turkey.

Murat Yarim, Universidad Ondokuz Mayis, Turquía

Universidad Ondokuz Mayis, Facultad de Medicina Veterinaria, Departamento de Patología, Samsun, Turkey.

Bugrahan Bekir Yagci, Universidad Kirikkale, Turquía

Universidad Kirikkale, Facultad de Medicina Veterinaria, Departamento de Medicina Interna, Kirikkale, Turkey.

Ayris Gokceoglu, Universidad Ondokuz Mayis, Turquía

Universidad Ondokuz Mayis, Facultad de Medicina Veterinaria, Departamento de Bioquímica, Samsun, Turkey.

Mahmut Sozmen, Universidad Ondokuz Mayis, Turquía

Universidad Ondokuz Mayis, Facultad de Medicina Veterinaria, Departamento de Patología, Samsun, Turkey.

Gokmen Zafer Pekmezci, Universidad Ondokuz Mayis, Turquía

Universidad Ondokuz Mayis, Facultad de Medicina Veterinaria, Departamento de Patología, Samsun, Turkey.

Efe Karaca, Universidad Ondokuz Mayis, Turquía

Universidad Ondokuz Mayis, Facultad de Medicina Veterinaria, Departamento de Medicina Interna, Samsun, Turkey.

Murat Guzel, Universidad Ondokuz Mayis, Turquía

Universidad Ondokuz Mayis, Facultad de Medicina Veterinaria, Departamento de Medicina Interna, Samsun, Turkey.

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