Diarrea viral bovina: patogénesis e inmunopatología

Diarrea viral bovina: patogénesis e inmunopatología

Publicado 2006-01-01

Abrir | Descargar
PDF FLIP
Cómo citar
Rondón B, L. (2006). Diarrea viral bovina: patogénesis e inmunopatología. Revista MVZ Córdoba, 11(1). https://doi.org/10.21897/rmvz.454
doi

https://doi.org/10.21897/rmvz.454
Dimensions
PlumX
Lang Rondón B
Mostrar biografía de los autores

Lang Rondón B

. Facultad de Medicina Veterinaria y Zootecnia. Instituto de Investigaciones de La Orinoquía Colombiana. Villavicencio
La diarrea viral bovina (DVB) representa un problema de ámbito mundial que causa considerables pérdidas tanto en ganado de carne como lechero, afectándolo de diversas formas las cuales están supeditadas a la edad del animal, estado inmunológico y momento de la gestación en el que se produce la infección. La DVB es causada por un virus ARN, género Pestivirus, familia Flaviviridae, el cual ha sido clasificado en 2 biotipos (citopático y no citopático) según su comportamiento en células de cultivo y en 2 genotipos (I y II) basados en su secuencia genética. Dependiendo de las cepas infectantes se presenta un cuadro clínico particular variando en severidad desde una forma subclínica, pasando por la forma clínica e incluso produciendo la fatal enfermedad de las mucosas o causando efectos deletéreos sobre el feto. A pesar de que en nuestro medio ya existen estudios sobre esta entidad, la implementación de metodologías diagnósticas constituye una limitante para el manejo de la misma. La presente revisión se enfoca en la patogenia e inmunopatología de la DVB.

Visitas del artículo 9254 | Visitas PDF

Descargas

Los datos de descarga todavía no están disponibles.
  1. Ramírez G, Vera V, Villamil L. Diarrea viral bovina – DVB: Inmunosupresión y efectos en la reproducción bovina. El Cebú 1999. 32-40.
  3. Jaime J, Villamil L, Vera V, Ramírez G. Infección persistente con el virus de la diarrea viral bovina (VDVB) en hatos lecheros de la sabana de Bogotá. Rev Med Vet Zoo 1996; 49:46-53.
  5. Benavides E, Ortiz D. Epidemiología del Aborto bovino en Colombia: Una aproximación Conceptual. 2003. Red de Epidemiología Veterinaria (Notiepivet).
  7. Saliki J, Fulton R, Hull S, Dubovi E. Microtiter virus isolation and enzyme immunoassays for detection of bovine viral diarrhea virus in cattle serum. J Clin Microb 1997; 35:803-807.
  9. Wengler G, Bradley M, Collet F, Heinz R, Schlesinger W, Strauss J. 1995. Flaviviridae. Virus Taxonomy. In: Baule C, Kulcsar G, Belak K, Albert M, Mittelholzer C, Soos T, et al. Pathogenesis of primary respiratory disease induced by isolates from a new genetic cluster of bovine viral diarrhea virus type I. J Clin Microbiol 2001; 39:146-153.
  11. Toplak I, Barlic-Maganja D, Hostnik P, Grom J. Genetic heterogeneity of bovine viral diarrhoea virus (BVDV) strains isolated in Slovenia. Slov Vet Res 2002; 39:113-123.
  13. Lambot M, Douart A, Joris E, Letesson J, Pastoret P. Characterization of immune response of cattle against non-cytopathic and cytopathic biotypes of bovine viral diarrhoea virus. J Gen Virol 1997; 78:1041-1047. http://dx.doi.org/10.1099/0022-1317-78-5-1041
  15. Katz J, Ridpath J, Bolin S. Presumptive diagnostic differentiation of hog cholera virus from bovine viral diarrhea and border disease viruses by using cDNA nestedamplification approach. J Clin Microbiol 1993; 31:565-568.
  17. Liang D, Sainz F, Ansari I, Gil L, Vassilev V, Donis R. The envelope glycoprotein E2 is a determinant of cell culture tropism in ruminant pestiviruses. J Gen Virol 2003; 84:1269-1274. http://dx.doi.org/10.1099/vir.0.18557-0
  19. Becher P, Orlich M, Shannon A, Horner G, Konig M, Thiel H. Phylogenetic analysis of pestivirus from domestic and wild ruminants. J Gen Virol 1997; 78:1357-1366. http://dx.doi.org/10.1099/0022-1317-78-6-1357
  21. Jubb K, Kennedy P, Palmer N. Pathology of domestic animals. Fourth edition. London. Academic Press Inc. 1993; 2:149-158.
  23. Laven R. Bovine Viral Diarrhoea Virus (BVDV). 2001. NADIS. Disponible en: www.mdc.org.uk/mdc-technichal/ documents/BVD.pdf.
  25. Uruno K, Shibata I, Nakane T. Detection of Bovine Viral Diarrhea Virus (BVDV) Using Reverse Transcription Polymerase Chain Reaction Assay. J Vet Med Sci 1998; 60:867-870. http://dx.doi.org/10.1292/jvms.60.867
  27. Adler H, Jungi W, Pfister H, Strasser M, Sileghem M, Peterhans E. Cytokine regulation by virus infection: bovine viral diarrhea virus, flavivirus, downregulates production of tumor necrosis factor alpha in macrophages in vitro. J Virol 1996; 70:2650-2653.
  29. Becher P, Orlich M, König M, Thiel J. Nonhomologous RNA Recombination in Bovine Viral Diarrhea Virus: Molecular Characterization of a Variety of Subgenomic RNAs Isolated during an Outbreak of Fatal Mucosal Disease. J Virol 1999; 73:5646–5653.
  31. Schweizer M, Peterhans E. Oxidative stress in cells infected with bovine viral diarrhoea virus: a crucial step in the induction of apoptosis. J Gen Virol 1999; 80:1147-1155. http://dx.doi.org/10.1099/0022-1317-80-5-1147
  33. Zhang G, Aldridge M, McCauley J. Cell death induced by cytopathic bovine viral diarrhea virus is mediated by apoptosis. J Gen Virol 1996; 77:1677-1681. http://dx.doi.org/10.1099/0022-1317-77-8-1677
  35. Dubovi E. Fatal BVD virus-induced disease: role of persistently infected animals. The Bov Proc 1986; (18).
  37. Peterhans E. 2002b. www.vetmed.unibe.ch/ .../Mikrobio-popmed/Peterhans/ BVD_Student_Bern_2002_05_21_handout_6_short.pdf.
  39. Baule C, Kulcsar G, Belak K, Albert M, Mittelholzer C, Soos T, Kucsera L, Belak S. Pathogenesis of primary respiratory disease induced by isolates from a new genetic cluster of bovine viral diarrhea virus type I. J Clin Microbiol 2001; 39:146-153. http://dx.doi.org/10.1128/JCM.39.1.146-153.2001
  41. Stokka G, Falkner R, Bierman P, Van Boening J. Bovine Virus Diarrhea. Kansas State University. Agricultural Experiment Station and Cooperative Extension Service. 2000.
  43. Pellerin C, Den Hurk V, Lecomte J, Tijssen P. Identification of a new group of bovine viral diarrhea virus strains associated with severe outbreaks and high mortalities. Virology 1994; 203:260-268. http://dx.doi.org/10.1006/viro.1994.1483
  45. Paton D, Sands J, Lowings J, Smith E, Ibata G, Edwards S. A proposed division of the pestivirus genus using monoclonal antibodies, supported by cross-neutralisation assays and genetic sequencing. Vet Res 1995; 26: 92-109.
  47. Morales S. Detección de terneros con infección congénita con el virus de la diarrea viral bovina en dos hatos lecheros de la provincia de Arequipa. 2001. (http:// sisbib.unmsm.edu.pe/bibvirtual/tesis/Salud/ Morales_C_S/Rev_Bibli.htm).
  49. Johnson C, Perez D, French R, Merrick W, Donis R. The NS5A protein of bovine viral diarrhoea virus interacts with the a subunit of translation elongation factor-1. J Gen Virol 2001; 82:2935–2943. http://dx.doi.org/10.1099/0022-1317-82-12-2935
  51. Donis R. Molecular biology of bovine viral diarrhea virus and its interactions with the host. Vet Clin North Amer 1995; 11:393- 423. http://dx.doi.org/10.1016/s0749-0720(15)30459-x
  53. Nelly J. Use serial analysis of gene expression to measure changes in gene expression in BVDV2 - infected MDBK cells. National Animal Disease Center (NADC). 2002. Disponible en: www.vetmed.iastate.edu/ services/institutes/iicab/ speaker%20abstracts.doc.
  55. Baker J. The clinical manifestations of bovine viral diarrhea infection. Vet Clin North Amer 1995; 11:425-445. http://dx.doi.org/10.1016/s0749-0720(15)30460-6
  57. Raymond G. BVDV – Bovine Virus Diarrhea Virus. Veterinarian's Corner 2002; 2(9).
  59. Heuschele W. Bovine viral diarrhea – Mucosal disease. Pennsylvania. Current Veterinary Therapy 3 Food Animal Practice. W.B. Saunders Company. 1993. 432-434.
  61. Brodersen B, Kelling C. Effect of concurrent experimentally induced bovine respiratory syncytial virus and bovine viral diarrhea virus infection on respiratory tract and enteric diseases in calves. Amer J Vet Res 1998; 59:1423-1430.
  63. Moennig V, Liess B. Pathogenesis of intrauterine infections with bovine viral diarrhea virus. Vet Clin North Amer 1995; 11:477-487. http://dx.doi.org/10.1016/s0749-0720(15)30462-x
  65. Ssetongo Y, Johnson R, Smith J. 1980. In: Moennig V, Liess B. Pathogenesis of intrauterine infections with bovine viral diarrhea virus. Vet Clin North Amer 1995; 11:477-487.
  67. Brock K, Lapin D, Skrade D. Embryo transfer from donnor cattle persistently infected with bovine viral diarrhea virus. Theriogenology 1997; 47:837-844. http://dx.doi.org/10.1016/S0093-691X(97)00039-3
  69. Fray M, Mann G, Bleach E, Knight P, Clarke M, Charleston B. Modulation of sex hormone secretion in cows by acute infection with bovine viral diarrhoea virus. Reproduction 2002; 123:281-289. http://dx.doi.org/10.1530/rep.0.1230281
  71. Brock K, Stringfellow D. 1993. In: Fray M, Prentice M, Clarke C, Charleston B. Immunohistochemical evidence for the localization of bovine viral diarrhea virus, a single-stranded RNA virus, in ovarian oocytes in the cow. Vet Pathol 1998; 35:253-259.
  73. Gillespie J, Schlafer D, Foote R, et al. 1990. In: Fray M, Prentice M, Clarke C, Charleston B. Immunohistochemical evidence for the localization of bovine viral diarrhea virus, a single-stranded RNA virus, in ovarian oocytes in the cow. Vet Pathol 1998; 35:253-259.
  75. Fray M, Prentice M, Clarke C, Charleston B. Immunohistochemical evidence for the localization of bovine viral diarrhea virus, a single-stranded RNA virus, in ovarian oocytes in the cow. Vet Pathol 1998; 35:253-259. http://dx.doi.org/10.1177/030098589803500403
  77. Booth P, Stevens D, Collins M, Brownlie J, 1995. In: Fray M, Prentice M, Clarke C, Charleston B. Immunohistochemical evidence for the localization of bovine viral diarrhea virus, a single-stranded RNA virus, in ovarian oocytes in the cow. Vet Pathol 1998; 35:253- 259. http://dx.doi.org/10.1177/030098589803500403
  79. Vanroose G, Nauwynck H, Van Soom A, Ysebaert M, Charlier G, Van Oostveldt P, et al. Structural Aspects of the Zona Pellucida of In Vitro-Produced Bovine Embryos: A Scanning Electron and Confocal Laser Scanning Microscopic Study Biol Reprod 2000; 62:463–469.
  81. Brown T, De La Hunta A, Scott F, et al. 1975. In: Moennig V. Liess B. Pathogenesis of intrauterine infections with bovine viral diarrhea virus. Vet Clin North Amer 1995; 11:477-487.
  83. Blood D, Henderson J, Radostis D. Medicina veterinaria. Espa-a. Editorial Interamericana de Espa-a Mc Graw Hill. 1992. 2:909-922.
  85. Sawyer et al., 1991. In: Bolin S. The pathogenesis of the mucosal disease. Vet Clin North Amer 1995; 11:489-500
  86. Charleston B, Fray M, Baigent S, Carr B, Morrison I. Establishment of persistent infection with non-cytopathic bovine viral diarrhoea virus in cattle is associated with failure to induce type I interferon. J Gen Virol 2001; 82:1893-1897. http://dx.doi.org/10.1099/0022-1317-82-8-1893
  88. Baigent S, Zhang G, Fray M, Flick-Smith, H, Goodbourn S, Mccauley J. Inhibition of beta interferon transcription by noncytopathogenic bovine viral diarrhea virus is through an interferon regulatory factor 3-dependent mechanism. J Virol 2002; 76:8979-8988. http://dx.doi.org/10.1128/JVI.76.18.8979-8988.2002
  90. Loehr B, Frey H, Moenning V, Greiser-Wilke I. Clinical-virological course after superinfection of persistently infected cattle with strains of cytpathogenic bovine viral diarrhoea virus. Deutsche Tieraerztliche Wochenschrift 1998; 105:201-205.
  92. Vera V. Genética molecular del virus de la diarrea viral bovina. Memorias: Aspectos básicos de la fisiología reproductiva y perspectivas de la biotecnología en Colombia. 1999. Oct. 24. Villavicencio, Meta.
  94. Schweizer M, Peterhans E. Noncytopathic bovine viral diarrhea virus inhibits doublestranded RNA-induced apoptosis and interferon synthesis. J Virol 2001; 75:4692- 4698. http://dx.doi.org/10.1128/JVI.75.10.4692-4698.2001
  96. Weinstock D, Bhudevi B, Castro A. Singletube single-enzyme reverse transcriptase PCR assay for detection of bovine viral diarrhea virus in pooled bovine serum. J Clin Microbiol 2001; 39:343-346. http://dx.doi.org/10.1128/JCM.39.1.343-346.2001
  98. Glew E, Howard C. Antigen-presenting cells from calves persistently infected with bovine viral diarrhoea virus, a member of the Flaviviridae, are not compromised in their ability to present viral antigen. J Gen Virol 2001; 82:1677-1685. http://dx.doi.org/10.1099/0022-1317-82-7-1677
  100. Frederiksen B, Press C, Loken T, Odegaard SA Distribution of viral antigen in uterus, placenta and foetus of cattle persistently infected with bovine virus diarrhoea. Vet Microbiol 1999; 64:109-122. http://dx.doi.org/10.1016/S0378-1135(98)00263-6
  102. Adler B, Adler H, Jungi T, Peterhans F. Macrophages infected with cytopathic bovine viral diarrhoea virus release a factor (s) capable of priming uninfected macrophages for activation-induced apoptosis. J Gen Virol 1997; 71:3255-3258.
  104. Lambot M, Hanon E, Lecomte C, Hamers C, Letesson J, Pastoret P. 1998a. Bovine viral diarrhoea virus induces apoptosis in blood mononuclear cells by a mechanism largely dependent on monocytes. J Gen Virol 1998; 79:1745-1749. http://dx.doi.org/10.1099/0022-1317-79-7-1745
  106. Tizard I. Inmunología veterinaria. Sexta edición. Mc Graw Hill Interamericana. 2002; 229, 449.
  108. Larsson B, Fossum C. Bovine virus diarrhoea virus induces in vitro a proliferative response of peripheral blood mononuclear cells from cattle immunized by infection. Vet Microbiol 1992; 31:317-325. http://dx.doi.org/10.1016/0378-1135(92)90124-C
  110. Lambot M, Joris E, Douart A, Lyaku J, Letesson J, Pastoret P. 1998b. Evidence for biotypespecific effects of bovine viral diarrhoea virus on biological responses in acutely infected calves. J Gen Virol 1998; 79:27–30. http://dx.doi.org/10.1099/0022-1317-79-1-27
  111. Howard C, Clarke M, Sopp P, et al. 1992. In: Potgieter L. Immunology of bovine viral diarrhea virus. Vet Clin North Amer 1995; 11:501-520.
  113. Howard C, Clarke M, Brownlie J. Protection against respiratory infection with bovine virus diarrhoea virus by passively acquired antibody. Vet Microbiol 1989; 19:195-203. http://dx.doi.org/10.1016/0378-1135(89)90066-7
  115. Rhodes S, Cocksedge J, Collins R, Morrison W. Differential cytokine responses of CD4+ and CD8+ T cells in response to bovine viral diarrhoea virus in cattle. J Gen Virol 1999; 80:1673–1679. http://dx.doi.org/10.1099/0022-1317-80-7-1673
  117. Bolin S, Ridpath J. In: Potgieter L. Immunology of bovine viral diarrhea virus. Vet Clin North Amer 1995; 11:501-520.
  119. Donis R, Dubovi E. Molecular specificity of the antibody responses of cattle naturally infected with cytopathic and noncytopathic of bovine biotypes of bovine virus diarrheamucosal disease virus. Virology 1987; 158:168-173. http://dx.doi.org/10.1016/0042-6822(87)90250-9
  121. Bolin S. The pathogenesis of the mucosal disease. Vet Clin North Amer 1995; 11:489- 500. http://dx.doi.org/10.1016/s0749-0720(15)30463-1
  123. Bolin S. Immunogens of bovine viral diarrhea virus. Vet Microbiol 1993; 37:263-271. http://dx.doi.org/10.1016/0378-1135(93)90028-6
  125. Balachandran S, Roberts C, Kipperman T, Bhalla N, Compans R, Archer D, Barber G. Alpha/beta interferons potentiate virus induce apoptosis through activation of the FADD/ caspase-8-death signaling pathway. J Virol 2000; 74:1513-1523.
  126. http://dx.doi.org/10.1128/JVI.74.3.1513-1523.2000
  128. Nakamura S, Shimazaki T, Sakamoto K, Fukusho A, Inoue Y, Ogawa N. 1995. In: Charleston B, Fray M, Baigent S, Carr B, Morrison I. Establishment of persistent infection with non-cytopathic bovine viral diarrhoea virus in cattle is associated with failure to induce type I interferon. J Gen Virol 2001; 82:1893-1897.
  130. Diderholm H, Dinter Z. 1966. In: Baigent S, Zhang G, Fray M, Flick-Smith H, Goodbourn, S, McCauley J. Inhibition of beta interferon transcription by noncytopathogenic bovine viral diarrhea virus is through an interferon regulatory factor 3-dependent mechanism. J Virol 2002; 76:8979-8988.
  132. Adler H, French B, Jungi T, Peterhans E. 1994. In: Glew, E.; Howard C. Antigen-presenting cells from calves persistently infected with bovine viral diarrhoea virus, a member of the Flaviviridae, are not compromised in their ability to present viral antigen. J Gen Virol 2001; 82:1677-1685. http://dx.doi.org/10.1099/0022-1317-82-7-1677
  136. Welsh et al. 1995. In: Glew E, Howard C. Antigen-presenting cells from calves persistently infected with bovine viral diarrhoea virus, a member of the Flaviviridae, are not compromised in their ability to present viral antigen. J Gen Virol 2001; 82:1677-1685. http://dx.doi.org/10.1099/0022-1317-82-7-1677
  138. Jaime J, Ramírez G. Inmunosupresión e inmunotolerancia asociados a infección por virus de la diarrea viral bovina (VDVB). Rev Med Vet Zoo 1996; 49:54-58.
  140. Buttke T, Sandstorm P. 1994. In: Schweizer M, Peterhans E. Oxidative stress in cells infected with bovine viral diarrhoea virus: a crucial step in the induction of apoptosis. J Gen Virol 1999; 80:1147-1155. http://dx.doi.org/10.1099/0022-1317-80-5-1147
  142. Peterhans E. Instituto de Virología Veterinaria. Universidad de Bern. Suiza. 2002a (www.vetmed.iastate.edu/services/institutes/ iicab/speaker%20abstracts.doc)

Información

SCImago Journal & Country Rank

0.6
2020CiteScore
 
 
28th percentile
Powered by  Scopus
Redib Widget
Tutoriales

Autores:

¿Cómo enviar un artículo?

Par evaluador:

¿Cómo evaluar un artículo?

Palabras clave

Código QR

Número actual

Perfil de Google Scholar

Más leídos en los últimos 30 días

Sistema OJS 3.4.0.3 - Metabiblioteca |