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Interpretation of doxycycline+chloroquine dual therapy for A. phagocytophilum infection in dogs

Interpretation of doxycycline+chloroquine dual therapy for A. phagocytophilum infection in dogs

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Ural, K. (2015). Interpretation of doxycycline+chloroquine dual therapy for A. phagocytophilum infection in dogs. Revista MVZ Córdoba, 20(2), 4556-4563.

Kerem Ural


Objective. A. phagocytophilum, an obligate intracellular pathogen, is a well-known agent causing granulocytic infections in both animals and humans. The purpose of the present study was to describe clinical course and consequences of Canine Granulocyctic Anaplasmosis among dogs in Aydin province, Turkey with special reference to hematological alterations and possible interpretations of doxycycline+chloroquine dual therapy. Materials and methods. A controlled clinical trial was carried out on 14 dogs referred and diagnosed as Canine Granulocyctic Anaplasmosis within Snap 4dx test. Relevant haematological data were recorded before (day 0) and after treatment (day 30) in both groups. Group I (n=7) were adminestered doxycycline (10 mg/kg q 12 h via oral route for 14 days) and chloroquine (2.5 mg/kg q 12 h for 14 days) and group II (n=7) received only doxycycline (10 mg/kg q 12 h for 14 days via oral route) therapy. Results. Doxycycline treatment hasten resolution of clinical signs in all dogs in about 2 to 7 days. There was no statistically significant differences among hematological variances detected (p>0.05). Conclusions. It may suggest that in conjunction with doxycycline chloroquine may have helped to speed up relevant clinical signs of CGA.


Objetivo. A. phagocytophilum, un patógeno intracelular obligado, es un agente ampliamente conocido que causa infecciones granulocíticas tanto en animales como en humanos. El propósito del presente estudio fue describir la evolución clínica y las consecuencias de la Anaplasmosis Granulocítica Canina en perros de la provincia de Aydin, Turquía, con especial referencia a las alteraciones hematológicas y a las posibles interpretaciones de una terapia dual de doxicilina+cloroquina. Materiales y métodos. Se realizó un estudio clínico controlado en 14 perros remitidos y diagnosticados con Anaplasmosis Granulocítica Canina usando de una prueba Snap 4dx. Se registraron datos hematológicos pertinentes antes (día 0) y después del tratamiento (día 30) en ambos grupos. Al Grupo I (n=7) se le administró doxicilina (10 mg/kg q 12 h por vía oral durante 14 días) y cloroquina (2.5 mg/kg q 12 h durante 14 días), mientras que el Grupo II (n=7) recibió una terapia únicamente con doxicilina (10 mg/kg q 12 h por vía oral durante 14 días). Resultados. La doxicilina aceleró la resolución de los signos clínicos en todos los perros en un periodo de aproximadamente 2 a 7 días. No se detectaron diferencias estadísticas significativas entre las variaciones hematológicas (p>0.05). Conclusiones. Lo anterior puede sugerir que, conjuntamente con la doxicilina, la cloroquina puede haber ayudado a acelerar los signos clínicos pertinentes de la Anaplasmosis Granulocítica Canina (AGC).


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