First report of avascular necrosis of the femoral head in a goat (Capra aegagrus hircus) in Peru

Primer reporte de necrosis avascular de cabeza femoral en una cabra (Capra aegagrus hircus) en el Perú

It is reported the case of a 7-month-old male goat of alpine race, who presented claudication of the right hind limb without definite cause. Clinical and radiographic examinations were performed, suggesting traumatic dislocation or avascular necrosis of the femoral head with consequent degenerative joint disease. It was performed a surgical treatment by an arthroplasty by excision of the head and neck of femur. The histopathological study by staining hematoxylin and eosin described: necrotic bone, lacunae containing necrotic osteocytes, as well as necrotic bone marrow. This information proved the diagnosis of avascular necrosis of the femoral head and neck. In the post-surgical period, the clinical recovery of the patient was considered good, the pain was mitigated and the function of the affected limb was improved. The present case is the first report of this disease in goats in Peru.

1. Jankovits DA, Liska WD, Kalis RH. Treatment of avascular necrosis of the femoral head in small dogs with micro total hip replacement. Vet Surg. 2012; 41(1):143-147. https://doi.org/10.1111/j.1532-950x.2011.00925.x
2. Boss JH, Misselevich I. Osteonecrosis of the Femoral Head of Laboratory Animals: The Lessons Learned from a Comparative Study of Osteonecrosis in Man and Experimental Animals. Vet Pathol. 2003; 40:345-354. https://doi.org/10.1354/vp.40-4-345
3. Cardoso CB, Rahal SC, Mamprim MJ, Salvador H, Melchert A, Figueroa J, et al. Avascular Necrosis of the Femoral Head in Dogs - Retrospective Study. Acta Scientiae Veterinariae. 2018; 46:1537. https://doi.org/10.22456/1679-9216.81845
4. Xie XH, Wang XL, Yang HL, Zhao DW, Qin L. Steroid-associated osteonecrosis: Epidemiology, pathophysiology, animal model, prevention, and potential treatments (an overview). J Orthop Translat. 2015; 3(2):58-70. https://doi.org/10.1016/j.jot.2014.12.002
5. Yang S, Wu X, Mei R, Yang C, Li J, Xu W, Ye S. Biomaterial-loaded allograft threaded cage for the treatment of femoral head osteonecrosis in a goat model. Biotechnol Bioeng. 2008; 100(3):560-56. https://doi.org/10.1002/bit.21792
6. DeCamp CE, Johnston SA, Déjardin LM, Schaefer SL. The hip joint. In: Piermattei D.L. (Ed). Brinker, Piermattei, and Flo’s handbook of small animal orthopedics and fracture repair. 5th edn. St. Louis: Elsevier; 2016. https://doi.org/10.1016/b978-1-4377-2364-9.00025-2
7. Scherzer C, Windhagen H, Nellesen J, Crostack HA, Rohn K, Witte F, Thorey F, et al. Comparative structural analysis of the canine femoral head in Legg-Calvé-Perthes disease. Vet Radiol Ultrasound. 2009; 50(4):404-411. https://doi.org/10.1111/j.1740-8261.2009.01557.x
8. Fitzpatrick, N, Pratola, L, Yeadon, R. Total hip replacement after failed femoral head and neck excision in two dogs and two cats. Vet Surg. 2011; 41:136–142. https://doi.org/10.1111/j.1532-950x.2011.00940.x
9. Harper T. Femoral Head and Neck Excision. Veterinary Clinics of North America: Small Animal Practice. 2017; 47:885–897. https://doi.org/10.1016/j.cvsm.2017.03.002
10. Zhu ZH, Gao YS, Luo SH, Zeng BF, Zhang CQ. An animal model of femoral head osteonecrosis induced by a single injection of absolute alcohol: An experimental study. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research. 2011; 17(4):97–102. https://doi.org/10.12659/msm.881708
11. Crawford C, Allen B, Powers D. Growth Profiles and Articular Cartilage Characterization in a Goat Model of Legg-Calvé-Perthes Disease. Journal of lnvestigative Surgery. 1995; 8:391-408. https://doi.org/10.3109/08941939509031606
12. Tang TT, Lu B, Yue B, Xie XH, Xie YZ, Dai KR, et al. Treatment of osteonecrosis of the femoral head with hBMP-2-gene-modified tissueengineered bone in goats. The Journal of Bone and Joint Surgery. 2007; 89(1):127-132. https://doi.org/10.1302/0301-620x.89b1.18350
13. Harwood D, Mueller K. Goat Medicine and Surgery. CRC Press. 2018. https://www.crcpress.com/Goat-Medicine-and-Surgery/Harwood-Mueller/p/book/9781498748636#googlePreviewContainer
14. Kobayashi R, Kurotaki T, Yamada N, Kumabe S, Doi T, Wako Y, Tsuchitani M. Spontaneous and bilateral necrosis of the femoral head in a young experimental beagle dog. Toxicol Pathol. 2015; 28:121–124. https://doi.org/10.1293/tox.2014-0060
15. Winders CLB, Vaughn WL, Birdwhistell KE, Holsworth IG, Franklin SP. Accuracy of femoral head and neck excision via a craniolateral approach or a ventral approach. Veterinary and Comparative Orthopaedics and Traumatology. 2018; 31(2):102-107. https://doi.org/10.3415/vcot-17-07-0099
16. Off W, Matis U. Excision arthroplasty of the hip joint in dogs and cats. Clinical, radiographic, and gait analysis findings from the Department of Surgery, Veterinary Faculty of the Ludwig-Maximilians-University of Munich, Germany. Vet Comp Orthop Traumatol. 2010; 23(5):297–305. https://www.orthovet.org/files/vcot_2010-23-5_13649_0.pdf