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Effects of L-Carnitine Supplementation on Ascites (Pulmonary Hypertension) Syndrome in the Broilers Grown at High Altitude

Efectos de la suplementación con L-carnitina en el síndrome de ascitis (hipertensión pulmonar) en los pollos de engorde cultivados a gran altura



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İkbal Coşkun, M., & Tekeli, A. (2018). Effects of L-Carnitine Supplementation on Ascites (Pulmonary Hypertension) Syndrome in the Broilers Grown at High Altitude. Journal MVZ Cordoba, 24(1), 7127-7136. https://doi.org/10.21897/rmvz.1523

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Muhammed İkbal Coşkun
Ahmet Tekeli

Objective. Investigate the effects of L-carnitine as a potential means of reducing the incidence of ascites in broilers and its relationship with physiological and biochemical paramaters. Material and methods. One-day-old 300 male broiler chicks (Ross 308) were used in the trial. The group without L-carnitine supplementation (0) was assigned as control and the groups that received 100, 150, 200 and 250 mg/L L-carnitine supplementation in water were assigned as treatment groups. The trial was completed in 35 days. Results. L-carnitine supplementation did not have any significant effect on live weight gain, feed consumption, water consumption and feed conversion ratio. Levels of blood plasma and hemogram parameters HDL, Triglyceride, CK, RBC and MCH were significantly affected by L-carnitine (p<0.05).  Blood gas parameter pH value was significantly affected by L-carnitine supplementation in the broilers with ascites. Blood gas pH value significantly increased with 100 mg/L L-carnitine supplementation compared to that of control (p<0.05). While blood pH was 7.21 in the animals with ascites, it was determined as 7.48 in healthy animals. Concentrations of SO2 and ctO2 were higher in healthy animals, while ctCO2P and hemoglobin concentrations were higher in ascitic animals (p<0.05). Conclusions. Ascites mortality rates starting from the control group were calculated respectively as %; 20.00, 18.33, 26.67, 28.33 and 28.33%. 76.71% of total ascites deaths were in the 5th week. It was concluded that low doses of L-carnitine supplementation may have positive effects in the broilers grown at high altitude.


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  1. Fathi E, Farahzadi R. Application of L-carnitine as nutritional supplement in veterinary medicine. Rom J Biochem. 2014; 51(1):31-41. URL Available in: http://journal.biochim.ro/archive/n51-1/pdfs_51-1/rjb51-1_03.pdf
  2. Harmeyer J. The physiological role of L-carnitine. Lohmann Information. 2002; 27:1-8. URL Available in: http://lohmann-information.de/content/l_i_27_article_3.pdf
  3. Flanagan JL, Simmons PA, Vehige J, Willcox MDP, Garrett Q. Role of carnitine in disease. Nutr Metab. 2010; 7(30):1-14. DOI: https://doi.org/10.1186/1743-7075-7-30
  4. Murali P, George SK, Ally K, Dipu MT. Effect of L-carnitine supplementation on growth performance, nutrient utilization and nitrogen balance of broilers fed with animal fat. Vet World. 2015; 8:482-486. DOI: https://doi.org/10.14202/vetworld.2015.482-486 PMid:27047119
  5. DiNicolantonio JJ, Lavie CJ, Fares H, Menezes AR, O’Keefe JH. L-carnitine in the secondary prevention of cardiovascular disease: systematic review and meta-analysis. Mayo Clin Proc 2013; 88(6):544-551. DOI: https://doi.org/10.1016/j.mayocp.2013.02.007 PMid:23597877
  6. Hurot JM, Cucherat M, Haugh M, Fouque D. Effects of L-carnitine supplementation in maintenance hemodialysis patients: A systematic review. J Am Soc Nephrol. 2002; 13:708-714. PMid:11856775
  7. Zhou X, Liu F, Zhai S. Effect of L-carnitine and/or L-acetyl-carnitine in nutrition treatment for male infertility: A systematic review. Asia Pac J Clin Nutr. 2007; 16(1):383-390. PMid:17392136
  8. Singh PK, Shekhar P, Kumar K. Nutritional and management control of ascites sydrome in poultry. Int J of Livest Prod. 2011; 2(8):117-123. URL Available in: https://academicjournals.org/journal/IJLP/article-abstract/DCC48CD1739
  9. Baghbanzadeh A, Decuypere E. Ascites syndrome in broilers: physiological and nutritional perspectives. Avian Path. 2008; 37(2):117-126. DOI: https://doi.org/10.1080/03079450801902062 PMid:18393088
  10. Olkowski AA, Classen HL, Kumor L. Left atrio-ventricular valve degeneration, left ventricular dilation and right ventricular failure: A possible association with pulmonary hypertansion and aetiology of ascites in broiler chickens. Avian Pathol. 1998; 27(1):51-59. DOI: https://doi.org/10.1080/03079459808419274 PMid:18484268
  11. Corduk M, Ceylan N. Ildiz F. Effects of dietary energy density and L-carnitine supplementation on growth performance, carcass traits and blood parameters of broiler chickens. S Afr J Anim Sci. 2007; 37(2):65-73. DOI: https://doi.org/10.4314/sajas.v37i2.4029
  12. Taklimi SMM, Ghazvinian K, Kasgari MRA. Effect of L-carnitine on performance and carcass quality of broiler chickens. Acad J of Sci Res. 2015; 3(3):50-54. URL Available in: https://academiapublishing.org/journals/ajsr/abstract/2015/Mar/Taklimi%20et%20al.htm
  13. Parsaeimehr K, Afrouziyeh M, Hoseinzadeh S. The effects of L-carnitine and different levels of anial fat on performance, carcass characteristics, some blodd parameters and immune response in broiler chicks. Iran j Appl Anim Sci. 2014; 4(3):561-566. URL Available in: http://ijas.iaurasht.ac.ir/article_513564.html
  14. Jalali SMA, Rabiei R. Kheiri F. Effects of dietary soybean and sunflower oils with and without L-carnitine supplementation on growth performance and blood biochemical parameters of broiler chicks. Arch Anim Breed. 2015; 58:387-394. DOI: https://doi.org/10.5194/aab-58-387-2015
  15. Wang YW, Ning D, Peng YZ, Guo YM. Effects of dietary L-carnitine supplementation on growth performance, organ weight, biochemical Parameters and Ascites Susceptibility in Broilers Reared Under Low-temperature Environment. Asian-Australas J Anim Sci. 2013; 26(2):233-240. DOI: https://doi.org/10.5713/ajas.2012.12407 PMid:25049781
  16. Geng A, Li B, Guo Y. Effects of dietary L-carnitine and coenzyme Q10 at different supplemental ages on growth performance and some ımmune response in ascites-susceptible broilers. Arch Anim Nutri. 2007; 61(1):50-60. DOI: https://doi.org/10.1080/17450390601117041 PMid:17361948
  17. Michalczuk M, Lukasiewicz M, Niemiec J, Wnuk A, Mroczek-Sosnowska N. Effetc of L-carnitine on performance and dressing percentage of broiler chickens. Ann Warsaw Univ of Life Sc SGGW Anim Sci. 2012; 51:89-99. URL Available in: http://annals-wuls.sggw.pl/?q=node/550
  18. Sharifi MR, Hassanpour H, Khajali F. Dietary L-carnitine aupplement counteracts pulmonary hypertensive response in broiler chickens fed reduced-protein diets and subjected to cool condition and hypobaric hypoxia. J Poultry Sci. 2015; 52:206-212. DOI: https://doi.org/10.2141/jpsa.0140205
  19. Zohair GAM, Al-Maktari GA, Amer MM. A comparative effect of mash and pellet feed on broiler perfromance and ascites at high altitude (Field study). Glob Vet. 2012; 9(2):154-159. URL Available in: https://www.idosi.org/gv/GV9(2)12/8.pdf
  20. Tan X, Hu S, Wang L. The effect of dietary L-carnitine supplementation on pulmonary hypertension syndrome mortality in broilers exposed to low temperatures. J Anim Phys Anim Nutri. 2008; 92:203-210. https://doi.org/10.1111/j.1439-0396.2007.00727.x PMid:18336417
  21. Hossininezhad MM, Irani M, Seidavi A. Dietary effects of L-carnitine supplement on performance and blood parameters of broiler chickens. J Food Agr Environ. 2011; 9(3-4):475-481. URL Available in: https://www.wflpublisher.com/Abstract/2307
  22. Asadi H, Sadeghi AA, Eila N, Aminafshar M. The effects of ractopamine, coenzyme Q and L-carnitine supplementation, individual or in combination, on the hematological parameters of broiler chickens. World Appl Sci J. 2013; 21(1):69-72. URL Available in: https://pdfs.semanticscholar.org/a3ae/afadcbdc1a5a6b40feadd74946b85148274f.pdf
  23. Murali P, George SK, Merey AD, Dipu MT, Narayanankutty K. Effects of L-carnitine supplementation on serum lipid profile of broiler chicken fed with animal fat. Inter J Agri & Food Sci Techn. 2013; 4(8):773-774. URL Available in: https://www.ripublication.com/ijafst_spl/ijafstv4n8spl_09.pdf
  24. Şimşek N, Karadeniz A, Bayraktaroğlu AG. Ratlarda periferal kan hücreleri üzerine L-karnitin, arı Sütü ve nar çekireğinin etkileri. Kafkas Univ Vet Fak Derg. 2009; 15(1):63-69. DOI: https://doi.org/10.9775/kvfd.2008.68-A
  25. Elgazzar UB, Ismael I, Ghanema A, Kalaba ZM. Effect of dietary L-carnitine supplementation on the concentration of circulating serum metabolites in growing New Zealand rabbits. Aust J Basic & Appl Sci. 2012; 6(2):80-84. URL Available in: http://www.ajbasweb.com/old/ajbas/2012/February/80-84.pdf
  26. Yousefi A, Khajali F, Hassanpour H, Khajali Z. Dietary L-carnitine improves pulmonary hypertensive response in broiler chickens subjected to hypobaric hypoxia. J Poultry Sci. 2013; 50:143-149. https://doi.org/10.2141/jpsa.0120145
  27. Albay R, Şen MK, Temelli S. Broiler üretiminde suların dezenfeksiyonunda iyot kullanımının karkas özellikleri üzerine etkisi. Van Vet J. 2002; 13(1-2):20-24. URL Available in: http://vfdergi.yyu.edu.tr/archive/2002/13_1-2/2002_13_(1-2)_20-24.pdf
  28. Van As P, Elferink MG, Closter AM, Vereijken A, Bovenhuis H, Crooijmans RPMA, Decuypere E, Groenen MAM. The Use of Blood Gas Parameters to Predict Ascites Susceptibility in Juvenile Broilers. Poult Sci. 2010; 89:1684-1691. https://doi.org/10.3382/ps.2009-00430 PMid:20634524
  29. Hafshejani EF, Gholami-Ahangaran M, Hosseni E. Study of blood cells, blood gases and thyroid hormones in broiler chickens suspected of ascites Syndrome. Glob Vet. 2012; 8(1):18-21. URL Available in: https://idosi.org/gv/GV8(1)12/4.pdf
  30. Tekeli A. Effects of ascites (Pulmonary hypertension) sydrome on blood gas, blood oximetrety parameters and heart sections of broilers grown at high altitude. J Anim Plant Sci. 2014; 24(4): 998-1002. URL Available in: http://www.thejaps.org.pk/docs/v-24-4/04.pdf

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