Skip to main navigation menu Skip to main content Skip to site footer

West Nile virus in Ecuador

Virus del Nilo Occidental en Ecuador



How to Cite
Coello Peralta, R. D., González González, M., & Martínez Cepeda, G. E. (2018). West Nile virus in Ecuador. Journal MVZ Cordoba, 24(1), 7151-7156. https://doi.org/10.21897/rmvz.1603

Dimensions
PlumX
Roberto Darwin Coello Peralta
Manuel González González
Galo Ernesto Martínez Cepeda

Roberto Darwin Coello Peralta,

Coordinador del Departamento de Investigación de la Facultad de Medicina Veterinaria y Zootecnia.


Manuel González González,

Docente investigador de la Cátedra de Virología y Medicina Tropical de la Facultad de Ciencias Médicas de la Universidad de Guayaquil


Galo Ernesto Martínez Cepeda,

Docente Investigador a Tiempo Completo de la Escuela de Medicina Veterinaria y Zootecnia


Several studies have been carried out to determine the presence and circulation of West Nile Virus (WNV) in several species that interact in important ecosystems of Ecuador, such as the Galapagos Islands, where presence and surveillance studies of WNV have been carried out in wild and migratory birds (2003) (2008 to 2010), penguins (2003 to 2004). Studies have also been carried out on birds from different locations in Guayaquil (2011), and on Jauneche horses (2007), but no virus has been demonstrated in any of them. Nevertheless, in the Abras de Mantequilla wetland, two studies were conducted in equines aged between 3 months to 12 years, all of them mixed race, male and female, with no previous vaccination history and with presence of symptoms only in the first study. In the two studies the serum analysis was performed by the ELISA technique (reactivity determination) and Plaque Reduction Neutralization Test (PRNT). In the first study, 8.12% (13/160) of reactivity was determined in 13 horses and 22.22% of reactivity in 2 of 9 people; and only 3.12% (5/160 horses) of the presence of IgM antibodies against WNV. In relation to the second study, 12.6% (52/412) reactivity and 10.4% (43/412 horses) confirmed the serological evidence of WNV, with a final prevalence of 6.76%. Consequently, the WNV is present and circulating in the equines of the Ecuadorian coastal zone, which is a potential risk to the public health, nevertheless there is no updated information on investigations conducted in this regard.


Article visits 2027 | PDF visits


Downloads

Download data is not yet available.
  1. Beck C, Jimenez MA, Leblond A, Durand B, Nowotny N, Leparc I. Flaviviruses in Europe: Complex Circulation Patterns and Their Consequences for the Diagnosis and Control of West Nile Disease. Int J Environ Res Public Health. 2013; 10 (11):6049-6083. DOI: https://doi.org/10.3390/ijerph10116049 PMid:24225644
  2. Nash D, Mostashari F, Fine A, Miller J, O’Leary D, Murray K, et al. The outbreak of West Nile virus infection in the New York City area in 1999. N Engl J Med. 2001; 344(24):1807-1814. https://doi.org/10.1056/NEJM200106143442401 PMid:11407341
  3. Anderson JF, Andreadis TG, Vossbrinck CR, Tirrell S, Wakem EM, French RA, et al. Isolation of West Nile virus from mosquitoes, crows, and a Cooper’s hawk in Connecticut. Science. 1999; 286(5448):2331-2333. https://doi.org/10.1126/science.286.5448.2331 PMid:10600741
  4. Lanciotti RS, Roehrig JT, Deubel V, Smith J, Parker M, Steele K, et al. Origin of the West Nile virus responsible for an outbreak of encephalitis in the northeastern United States. Science. 1999; 286(5448):2333-2337. https://doi.org/10.1126/science.286.5448.2333 PMid:10600742
  5. Garcia MN, Hasbun R, Murray KO. Persistence of West Nile virus. Microbes Infect. 2015; 17(2):163-168. https://doi.org/10.1016/j.micinf.2014.12.003 PMid:25499188
  6. Bhuvanakantham R, Cheong YK, Ng ML. West Nile virus capsid protein interaction with importin and HDM2 protein is regulated by protein kinase C-mediated phosphorylation. Microbes Infect. 2010; 12(8-9):615-625. https://doi.org/10.1016/j.micinf.2010.04.005 PMid:20417716
  7. Brinton MA. The molecular biology of West Nile Virus: a new invader of the western hemisphere. Annu Rev Microbiol. 2002; 56:371-402. https://doi.org/10.1146/annurev.micro.56.012302.160654 PMid:12142476
  8. Takahashi H, Ohtaki N, Maeda-Sato M, Tanaka M, Tanaka K, Sawa H, et al. Effects of the number of amino acid residues in the signal segment upstream or downstream of the NS2B-3 cleavage site on production and secretion of prM/M-E virus-like particles of West Nile virus. Microbes Infect. 2009; 11(13):1019-1028. https://doi.org/10.1016/j.micinf.2009.07.009 PMid:19647801
  9. Reisen WK. Ecology of West Nile Virus in North America. Viruses. 2013; 5(9):2079-105. https://doi.org/10.3390/v5092079 PMid:24008376
  10. Mostashari F, Bunning ML, Kitsutani PT, Singer DA, Nash D, Cooper MJ, et al. Epidemic West Nile encephalitis, New York, 1999: results of a household-based seroepidemiological survey. Lancet. 2001; 358(9278):261-264. https://doi.org/10.1016/S0140-6736(01)05480-0
  11. Díaz LA, Quaglia A, Flores FS, Contigiani MS. Virus West Nile en Argentina: un agente infeccioso emergente que plantea nuevos desafíos. El hornero. 2011; 26(1):5–28. https://digital.bl.fcen.uba.ar/download/hornero/hornero_v026_n01_p005.pdf
  12. Hart J, Jr., Tillman G, Kraut MA, Chiang HS, Strain JF, Li Y, et al. West Nile virus neuroinvasive disease: neurological manifestations and prospective longitudinal outcomes. BMC Infect Dis. 2014; 14:248. https://doi.org/10.1186/1471-2334-14-248 PMid:24884681
  13. Castillo-Olivares J, Wood J. West Nile virus infection of horses. BMC Vet Res. 2004; 35(4):467-483. https://doi.org/10.1051/vetres:2004022 PMid:15236677
  14. Chancey C, Grinev A, Volkova E, Rios M. The global ecology and epidemiology of West Nile virus. Biomed Res Int. 2015:1-20. https://doi.org/10.1155/2015/376230 PMid:25866777
  15. Morales MA, Barrandeguy M, Fabbri C, Garcia JB, Vissani A, Trono K, et al. West Nile virus isolation from equines in Argentina, 2006. Emerg Infect Dis. 2006; 12(10):1559-1561. https://doi.org/10.3201/eid1210.060852 PMid:17176571
  16. Komar N, Clark GG. West Nile virus activity in Latin America and the Caribbean. Rev Panam Salud Publica. 2006; 19(2):112-127. https://doi.org/10.1590/S1020-49892006000200006 PMid:16551385
  17. Mattar S, Edwards E, Laguado J, Gonzalez M, Alvarez J, Komar N. West Nile virus antibodies in Colombian horses. Emerg Infect Dis. 2005; 11(9):1497-1498. https://doi.org/10.3201/eid1109.050426 PMid:16673523
  18. Bosch I, Herrera F, Navarro JC, Lentino M, Dupuis A, Maffei J, et al. West Nile virus, Venezuela. Emerg Infect Dis. 2007; 13(4):651-653. https://doi.org/10.3201/eid1304.061383 PMid:17561567
  19. Tauro L, Marino B, Diaz LA, Lucca E, Gallozo D, Spinsanti L, et al. Serological detection of St. Louis encephalitis virus and West Nile virus in equines from Santa Fe, Argentina. Mem Inst Oswaldo Cruz. 2012; 107(4):553-556. https://doi.org/10.1590/S0074-02762012000400019 PMid:22666870
  20. Pauvolid-Correa A, Morales MA, Levis S, Figueiredo LT, Couto-Lima D, Campos Z, et al. Neutralising antibodies for West Nile virus in horses from Brazilian Pantanal. Mem Inst Oswaldo Cruz. 2011; 106(4):467-474. https://doi.org/10.1590/S0074-02762011000400014 PMid:21739036
  21. Burgueno A, Spinsanti L, Diaz LA, Rivarola ME, Arbiza J, Contigiani M, et al. Seroprevalence of St. Louis encephalitis virus and West Nile virus (Flavivirus, Flaviviridae) in horses, Uruguay. Biomed Res Int. 2013; 2013:582957. https://doi.org/10.1155/2013/582957 PMid:24490165
  22. Faggioni G, De Santis R, Pomponi A, Grottola A, Serpini GF, Meacci M, et al. Prevalence of Usutu and West Nile virus antibodies in human sera, Modena, Italy, 2012. J Med Virol. 2018 https://doi.org/10.1002/jmv.25230
  23. Travis EK, Vargas FH, Merkel J, Gottdenker N, Miller RE, Parker PG. Hematology, plasma chemistry, and serology of the flightless cormorant (Phalacrocorax harrisi) in the Galapagos Islands, Ecuador. J Wildl Dis. 2006; 42(1):133-141. https://doi.org/10.7589/0090-3558-42.1.133 PMid:16699155
  24. Travis EK, Vargas FH, Merkel J, Gottdenker N, Miller RE, Parker PG. Hematology, serum chemistry, and serology of Galapagos penguins (Spheniscus mendiculus) in the Galapagos Islands, Ecuador. J Wildl Dis. 2006; 42(3):625-632. https://doi.org/10.7589/0090-3558-42.3.625 PMid:17092893
  25. Eastwood G, Goodman SJ, Hilgert N, Cruz M, Kramer LD, Cunningham AA. Using Avian Surveillance in Ecuador to Assess the Imminence of West Nile Virus Incursion to Galápagos. EcoHealth. 2014; 11(1):53-62. https://doi.org/10.1007/s10393-014-0911-5 PMid:24796792
  26. Coello Peralta RD, Diaz Castillo A, Medrano JB. Detección del Virus del Nilo Occidental en Equinos del Ecuador: Primera presencia serológica del virus del Nilo Occcidental en equinos de humedales en el Ecuador: 2007-2009. ed. Madrid - España: Editorial Académica Española; 2016.
  27. Ministerio del Ambiente del Ecuador. Humedales del Ecuador. Quito - Ecuador: 2018 [cited 20-06-2018]. URL Available in: http://suia.ambiente.gob.ec/web/humedales/documentos
  28. (OIE) Organización Mundial de Sanidad Animal. Fiebre del Nilo Occidental. Paris - Francia: OIE; 2013 [cited 13-03-2018]. URL Available in: http://www.oie.int/fileadmin/Home/esp/Health_standards/tahm/2.01.24_WEST_NILE.pdf
  29. Malan AK, Martins TB, Hill HR, Litwin CM. Evaluations of commercial West Nile virus immunoglobulin G (IgG) and IgM enzyme immunoassays show the value of continuous validation. J Clin Microbiol. 2004; 42(2):727-733. https://doi.org/10.1128/JCM.42.2.727-733.2004 PMid:14766844
  30. Blitvich BJ, Fernandez-Salas I, Contreras-Cordero JF, Marlenee NL, Gonzalez-Rojas JI, Komar N, et al. Serologic evidence of West Nile virus infection in horses, Coahuila State, Mexico. Emerg Infect Dis. 2003; 9(7):853-856. https://doi.org/10.3201/eid0907.030166 PMID: 12890327
  31. Barrera R, Hunsperger E, Munoz-Jordan JL, Amador M, Diaz A, Smith J, et al. First isolation of West Nile virus in the Caribbean. The Am J Trop Med Hyg. 2008; 78(4):666-668. https://doi.org/10.4269/ajtmh.2008.78.666 PMid:18385366
  32. Earley E, Peralta PH, Johnson KM. A plaque neutralization method for arboviruses. Proc Soc Exp Biol Med. 1967; 125(3):741-747. https://doi.org/10.3181/00379727-125-32194 PMid:15938255
  33. Vázquez González a. Busqueda de flavivirus en mosquitos de humedales espa-oles: análisis moleculares del virus west nile y Otros flavivirus. [Tesis Doctoral]. Madrid: Universidad Complutense de Madrid; 2010.
  34. Mattar S, Komar N, Young G, Alvarez J, Gonzalez M. Seroconversion for West Nile and St. Louis encephalitis viruses among sentinel horses in Colombia. Mem Inst Oswaldo Cruz. 2011; 106(8):976-979. https://doi.org/10.1590/S0074-02762011000800012 PMid:22241119
  35. Melandri V, Guimaraes AE, Komar N, Nogueira ML, Mondini A, Fernandez-Sesma A, et al. Serological detection of West Nile virus in horses and chicken from Pantanal, Brazil. Mem Inst Oswaldo Cruz. 2012; 107(8):1073-1075. https://doi.org/10.1590/S0074-02762012000800020 PMid:23295763
  36. Coello Peralta RD, González González M, Martínez Cepeda GE. Coinfection of two arboviruses (VNO and VESL) in equids of the “Abras de Mantequilla” wetland, Ecuador. J Electr Vet. 2018; 19(6):1-12. URL Available in: http://www.veterinaria.org/revistas/redvet/n060618/061809.pdf

Sistema OJS 3.4.0.3 - Metabiblioteca |