Challenges in the diagnosis and control of Marek’s disease virus in Colombia
Retos en el diagnóstico y control del virus de la enfermedad de Marek en Colombia
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Although the Colombian poultry industry has almost doubled its production in the last decade, our ability to diagnose and characterize avian pathogens is deficient, and there is little information of the circulating viral pathogens. One of these pathogens is Marek disease virus (MDV), which is an immunosuppressive agent that can cause high mortality rates and substantial production losses. Currently, there are few documented clinical cases due to the implementation of mass vaccination programs with GaHV-2 strains (serotype I) and HVT (serotype III). However, losses in production rates are likely occurring due to immunosuppression and subclinical infections. The objective of this review is to describe MDV and the current status of the infection in Colombia.
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1. Dufour-Zavala L. A Laboratory Manual for the Isolation, Identification, and Characterization of Avian Pathogens. 6th Edition, Chapter 52. Jacksonville, Fl. United States: American Association of Avian Pathologists; 2016.
2. Shahzad MK, Majeed KA, Younus M. Marek’ s Disease: A Mini-Review. IJAVMS. 2007; 1:4–8.
3. Swayne D, JR Glisson, LR McDougald, LK Nolan, DL Suarez, VL Nair. Diseases of poultry. 13th Edition. John Wiley & Sons, inc; 2017. URL Available in: https://onlinelibrary.wiley.com/doi/book/10.1002/9781119421481
4. Kato S, Horiuchi T, Mikami T, Hirai K. (Eds.) Advances in Marek’s Disease Research. Osaka Japanese Association on Marek’s Disease: Japon; 1988.
5. Davidson F, Nair V. (Editors). Marek disease virus: An Evolving Problem. 1ed. Compton, UK: Elsevier BV; 2004.
6. Silva RF, Cheng HH, Coussens PM, Lee LF, Velicer LF (Eds.) Current Research on Marek’s Disease Kennett Square PA. United States: American Association of Avian Pathologists; 1996.
7. Cuello S, Vega A, Relova D. Enfermedad de Marek: Breve reseña bibliográfica y situación actual. Rev Electrónica Vet. 2014; 15(10):1–19. Available from: http://www.veterinaria.org/revistas/redvet/n101014/101405.pdf
8. Gimeno IM. Marek’s disease vaccines: A solution for today but a worry for tomorrow?. Vaccine. 2008; 26(8):C31–41. DOI: https://doi.org/10.1016/j.vaccine.2008.04.009
9. Nair V. Evolution of Marek’s disease - A paradigm for incessant race between the pathogen and the host. Vet J. 2005; 170:175–83.
10. Ross N, Sullivan G, Coudert F. Influence of chicken genotype on protection against Marek’s disease by a Herpesvirus of turkeys recombinant expressing glycoprotein B (gB) of Marek’s disease virus. Vaccine. 1996; 14(3):187–189 DOI: https://doi.org/10.1016/0264-410X(95)00215-M
11. Biggs PM. The history and biology of Marek’s disease virus. In: Hirai K, editor. Current Topics in Microbiology and Immunology,. Berlin: Springer-Verlag; 2001.
12. Fehler F. Marek’ s Disease: History, actual and future perspectives. Lohman Inf. 2001; 25:1–5. URL Available: http://lohmann-information.de/content/l_i_25_article_4.pdf
13. Instituto Colombiano Agropecuario (ICA). RESOLUCIÓN No. 587 (Diciembre 27 de 1973) “Por la cual se dictan medidas para el control de la enfermedad de Marek en las aves de corral.” [cited 2015 Feb 25]. Colombia; 1973.
14. Gimeno IM, Fletcher OJ, Montiel E, Osuna ON, Majó RD, Smyth JA, et al. Enfermedades inmunosupresoras en avicultura. Servet E: España;. 2013.
15. Witter RL, Calnek BW, Buscaglia C, Gimeno IM, Schat KA. Classification of Marek’s disease viruses according to pathotype: philosophy and methodology. Avian Pathol. 2005; 34(2):75–90. DOI: http://dx.doi.org/10.1080/03079450500059255
16. Lopez-Osorio S, Piedrahita D, Espinal-Restrepo MA, Ramirez-Nieto GC, Nair V, Williams SM, et al. Molecular characterization of Marek’ s disease virus in a poultry layer farm from Colombia. Poult Sci. 2017; 96(6): 1598–1608. DOI: http://dx.doi.org/10.3382/ps/pew464
17. Lopez-Osorio S, Chaparro JJ, Piedrahita D, Ramírez GC. Presencia de los Virus de la Enfermedad de Marek y Anemia Infecciosa Aviar en aves de levante del norte y oriente del departamento de Antioquia [Maestría en Ciencias Veterinarias]. Colombia: Universidad de Antioquia; 2015.
18. Gong Z, Zhang L, Wang J, Chen L, Shan H, Wang Z, et al. Isolation and analysis of a very virulent Marek’s disease virus strain in China. Virol J. 2013; 10(1):155. DOI: http://dx.doi.org/10.1186/1743-422X-10-155
19. Zhang Z, Liu S, Ma C, Zhao P, Cui Z. Absolute quantification of a very virulent Marek’s disease virus dynamic quantity and distributions in different tissues 1. Poult Sci. 2015; 94(6):1150–7.DOI: https://doi.org/10.3382/ps/pev063
20. Atkins KE, Read AF, Savill NJ, Renz KG, Islam AF, Walkden-Brown SW, et al. Vaccination and reduced cohort duration can drive virulence evolution: Marek’s disease virus and industrialized agriculture. Evolution. 2013; 67:851-860. DOI: https://doi.org/10.1111/j.1558-5646.2012.01803.x
21. Silva RF, Cheng HH,. Coussens PM,. Lee LF, Velicer LF. Current Research on Marek’s Disease. Kennett Square: American Association of Avian Pathologists; 1996.
22. Shek WR, Schat KA, Calnek BW. Characterization of non-oncogenic Marek’s disease virus-infected and turkey herpesvirus infected lymphocytes. J Gen Virol. 1982; 63:333–341. https://dx.doi.org/10.1099/0022-1317-63-2-333
23. Calnek BW, Schat KA, Ross LJN, Shek WR, Chen CLH. Further characterization of Marek’s disease virus infected lymphocytes. I. In vivo infection. Int J Cancer. 1984; 33:389–398. PMID: 6321364
24. Calnek BW, Schat KA, Ross LJN, Chen CLH. Further characterization of Marek’s disease virus infected lymphocytes. II. In vitro infection. Int J Cancer. 1984; 33:399–406. PMID: 6321365
25. Davidson I, Borenshtain R. Novel applications of feather tip extracts from MDV-infected chickens; diagnosis of commercial broilers, whole genome separation by PFGE and synchronic mucosal infection FEMS. Immunol Med Microbiol. 2003; 38:199–203. DOI: https://doi.org/10.1016/S0928-8244(03)00177-9
26. Davidson I, Artzi N, Shkoda I, Lublin A, Loeb E, Schat KA. The contribution of feathers in the spread of chicken anemia virus. Virus Res. 2008; 132(1–2):152–9. DOI: https://doi.org/10.1016/j.virusres.2007.11.012
27. Haq K, Schat KA, Sharif. S. Immunity to Marek’s disease: Where are we now?. Dev Comp Immunol. 2013; 41:439–446. DOI: https://doi.org/10.1016/j.dci.2013.04.001
28. Omar AR, Schat KA. Syngeneic Marek’s disease virus (MDV)-specific cell-mediated immune responses against immediate early, late, and unique MDV proteins. Virology. 1996; 222:87–99. https://doi.org/10.1006/viro.1996.0400 PMID: 8806490
29. Sharma JM, Witter RL. The effect of B-cell immunosuppression on age-related resistance of chickens to Marek’s disease. Cancer Res. 1975; 35:711–717. PMID: 234791
30. Parvizi P, Abdul-Careem MF, K. Haq N, Thanthrige-Don, Schat KA. Immune responses against Marek’s disease virus. Animal Health Research Reviews. 2010; 11(2):123–134. DOI: https://doi.org/10.1017/S1466252310000022
31. Becker Y, Asher Y, Tabor E, Davidson I, Malkinson M, Weisman Y. Polymerase chain reaction for differentiation between pathogenic and non-pathogenic serotype 1 Marek’s disease viruses (MDV) and vaccine viruses of MDV-serotypes 2 and 3. J Virol Methods. 1992; 40(3):307–22. PMID: 1335457
32. Wei X, Shi X, Zhao Y, Zhang J, Wang M, Liu C, et al. Development of a rapid and specific loop-mediated isothermal amplification detection method that targets Marek’s disease virus meq gene. J Virol Methods. 2012; 183(2):196–200. DOI: https://doi.org/10.1016/j.jviromet.2012.04.014
33. Davidson I, Borenshtain R, Weisman Y. Molecular identification of the Marek’s disease virus vaccine strain CVI988 in vaccinated chickens. J Vet Med B Infect Dis Vet Public Health. 2002; 49(2):83–87. PMID: 12002424
34. Baigent SJ, Petherbridge LJ, Howes K, Smith LP, Currie RJW, Nair VK. Absolute quantitation of Marek’s disease virus genome copy number in chicken feather and lymphocyte samples using real-time PCR. J Virol Methods. 2005; 123(1):53–64. DOI: https://doi.org/10.1016/j.jviromet.2004.08.019
35. Islam A, Cheetham BF, Mahony TJ, Young PL, Walkden-Brown SW. Absolute quantitation of Marek’s disease virus and Herpesvirus of turkeys in chicken lymphocyte, feather tip and dust samples using real-time PCR. J Virol Methods. 2006; 132(1–2):127–34. DOI: https://doi.org/10.1016/j.jviromet.2005.10.009
36. Levy H, Maray T, Davidson I, Malkinson M, Becker Y, Maray T, et al. Replication of Marek ’ s disease virus in chicken feather tips containing vaccinal turkey herpesvirus DNA Replication of Marek ’ s disease virus in chicken feather tips containing vaccinal turkey herpesvirus DNA. Avian Pathol. 2007; 20(1):35–44.DOI: https://doi.org/10.1080/03079459108418739
37. Baigent SJ, Smith LP, Petherbridge LJ, Nair VK. Differential quantification of cloned CVI988 vaccine strain and virulent RB-1B strain of Marek’s disease viruses in chicken tissues, using real-time PCR. Res Vet Sci. 2011; 91(1):167–74. DOI: https://doi.org/10.1016/j.rvsc.2010.08.002
38. Islam T, Walkden-brown SW, Renz KG, Islam AFMF, Ralapanawe S. Replication kinetics and shedding of very virulent Marek’ s disease virus and vaccinal Rispens / CVI988 virus during single and mixed infections varying in order and interval between infections. Vet Microbiol. 2014; 173(3–4):208–23. http://dx.doi.org/10.1016/j.vetmic.2014.07.027
39. Walkden-Brown SW, Islam A, Islam A, Burgess SK, Groves PJ, Cooke J. Pathotyping of Australian isolates of Marek’s disease virus in commercial broiler chickens vaccinated with herpesvirus of turkeys (HVT) or bivalent (HVT/SB1) vaccine and association with viral load in the spleen and feather dander. Aust Vet J. 2013; 91(8):341–50. http://dx.doi.org/10.1111/avj.12084
40. Witter RL, Calnek BW, Buscaglia C, Gimeno IM, Schat KA. Classification of Marek’s disease viruses according to pathotype: philosophy and methodology. Avian Pathol. 2005; 34:75–90. DOI: https://doi.org/10.1080/03079450500059255
41. Witter RL. Increased Virulence of Marek’ s Disease Virus Field Isolates. Avian Dis. 1997; 41(1):149–63. PMID: 9087332
42. Dudnikova E, Norkina S, Vlasov A, Slobodchuk A, Lee LF, Witter RL. Evaluation of Marek’s disease field isolates by the “best fit” pathotyping assay. Avian Pathol; 2007; 36(2):135–43. http://dx.doi.org/10.1080/03079450701209857
43. Calnek BW, Harris RW, Buscaglia C, Schat KA, Lucio. B. Relationship between the immunosuppressive potential and the pathotype of Marek’s disease virus isolates. Avian Dis. 1998; 42(1):124–132. PMID: 9533089
44. Zhang Y, Li Z, Bao K, Lv H, Gao Y, Gao H, et al. Pathogenic characteristics of Marek’s disease virus field strains prevalent in China and the effectiveness of existing vaccines against them. Vet Microbiol. 2015; 177(1–2):62–8. DOI: https://doi.org/10.1016/j.vetmic.2014.12.020
45. Renz KG, Islam A, Cheetham BF, Walkden-Brown SW. Absolute quantification using real-time polymerase chain reaction of Marek’s disease virus serotype 2 in field dust samples, feather tips and spleens. J Virol Methods. 2006; 135(2):186–91. DOI: https://doi.org/10.1016/j.jviromet.2006.03.017
46. Haridy M, Goryo M, Sasaki J, Okada K. Pathological and immunohistochemical study of chickens with co-infection of Marek’s disease virus and chicken anaemia virus,. Avian Pathol. 2009; 38(6):469-83. DOI: https://doi.org/10.1080/03079450903349162
47. Xiu-guo D, Guo Z, Zi-qiang C, Gui-hua W, Xiang-kai M, Ting-ting G, et al. Dynamic Pathology and Antigen Location Study on Broiler Breeders with Coinfection of Marek’s Disease Virus and Reticuloendotheliosis Virus. Agric Sci China. 2008; 7(11):1387–93. DOI: https://doi.org/10.1016/S1671-2927(08)60189-3
48. Baigent SJ, Smith LP, Nair VK, Currie RJW. Vaccinal control of Marek’s disease: current challenges, and future strategies to maximize protection. Vet Immunol Immunopathol. 2006; 112(1–2):78–86. DOI: https://doi.org/10.1016/j.vetimm.2006.03.014
49. Ralapanawe S. Field studies on the detection, persistence and spread of the Rispens CVI988 vaccine virus and the extent of co- infection with Marek ’ s disease virus. Aust Vet J. 2016; 94(9):329-37. doi: https://doi.org/10.1111/avj.12479
50. Davison F, Nair V. Marek´s Disease: An evolving Problem. 1st ed.. Compton, UK: Elsevier B.V.; 2004.
51. López S, Piedrahita D, Ramírez GC, Aranzazu D, Williams S, Chaparro J. La inmunodepresión subclínica, un problema importante en los sistemas de producción avícola. Plumazos. 2015; (51):14–23. URL Available in: http://pubhtml5.com/fcla/ohnv/basic
52. Osterrieder N, Kamil JP, Schumacher D, Tischer BK, Trapp S. Marek’s disease virus: from miasma to model. Nat Rev Microbiol. 2006; 4:283–294. DOI: https://doi.org/10.1038/nrmicro1382
53. Lopera Toro PA. Evaluación epidemiológica molecular de las cepas circulantes del virus de la enfermedad de Marek en brotes presentados en Colombia durante el período de 2000 al 2012. [Tesis de Doctorado en Ciencias Animales]. Colombia: Universidad de Antioquia; 2017.