Search for Hantavirus and Arenavirus in rodents from Villavicencio, Colombia

Búsqueda de Hantavirus y Arenavirus en roedores de Villavicencio, Colombia

Objective. To search Hantavirus and Arenavirus in small rodents and establish their spatial distribution in disturbed ecosystems in the municipality of Villavicencio, Meta, Colombia. Materials and method. A descriptive cross-sectional study was carried out from October 2018 to October 2019 in periurban and rural areas of the municipality of Villavicencio. Rodents were captured using Sherman-type traps and molecular detection of Hantavirus and Arenavirus was carried out by Polymerase chain Reaction technique. Results. A total of 50 rodents were captured belonged to 3 families and six species, the Muridae (76%) with the highest number of captured individuals, Cricetidae (22%) and Echimydae (2%). All samples were negative for the molecular markers of Hantavirus and Arenavirus. Conclusions. The study of mammalian hosts, particularly small rodents contribute to monitor diseases transmitted by these small mammals that act as reservoirs.

1. Han B, Kramer A, Drake J. Global Patterns of Zoonotic Disease in Mammals. Trends Parasitol. 2016; 32(7):565-577. https://doi.org/10.1016/j.pt.2016.04.007
2. Blanco P, Corrales H, Arroyo S, Perez J, Álvarez L, Castelar A. Comunidad de roedores en el municipio de san marcos, sucre, colombia. Rev Colombiana Cienc Anim. Recia. 2012; 4(1):89-101. https://doi.org/10.24188/recia.v4.n1.2012.278
3. Villalobos D, Ramírez JD, Chacón E, Pineda W, Rodríguez B. Clave para la identificación de los roedores de Costa Rica. Primera Ed. Costa Rica: Universidad de Costa Rica; 2016.46. https://www.academia.edu/29882897/Clave_para_la_identificaci%C3%B3n_de_los_roedores_de_Costa_Rica
4. Picco N, Martin V, Motta C. Determinación de bacterias zoonóticas transmitidas por roedores. Argentina; 2015. Ed Académica española. http://dx.doi.org/10.13140/RG.2.1.4241.2969
5. Bordes F, Blasdell K, Morand S. Transmission ecology of rodent-borne diseases: New frontiers. Integrative zoology. septiembre de 2015;10(5):424-35. https://doi.org/10.1111/1749-4877.12149
6. Vélez F, Pérez J. Remoción de semillas por roedores en un fragmento de bosque seco tropical (Risaralda-Colombia). Rev MVZ Córdoba. 2010; 15(3):2223-33. https://revistamvz.unicordoba.edu.co/article/view/309
7. Ministerio de salud y protección social. Manual para el control integral de roedores. Colombia; 2012 p. 1-82. https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/VS/PP/SA/manual-integral-de-roedores.pdf
8. Acero M. Zoonosis y otros problemas de salud pública relacionados con los animales: reflexiones a propósito de sus aproximaciones teóricas y metodológicas. Rev. Gerenc. Polít. Salud. 2016; 15 (31): 232-245. http://dx.doi.org/10.11144/Javeriana.rgyps15-31
9. Cortez V, Canal E, Dupont JC, Quevedo T, Albujar C, Chang T-C, et al. Identification of Leptospira and Bartonella among rodents collected across a habitat disturbance gradient along the Inter-Oceanic Highway in the southern Amazon Basin of Peru. PloS one. 2018;13(10):e0205068. https://pubmed.ncbi.nlm.nih.gov/30300359/
10. Montoya C, Diaz F, Rodas J. Recent evidence of hantavirus circulation in the American tropic. Viruses. 2014;6(3):1274-93. Disponible en: https://pubmed.ncbi.nlm.nih.gov/24638203
11. Sánchez L. Dengue, leptospirosis, hantavirosis y rickettsiosis en pacientes con síndrome febril agudo no palúdico en el meta, Colombia (2013-2014). Instituto de Medicina Tropical Pedro Kourí; 2017. http://tesis.sld.cu/index.php?P=BrowseResources&ID=3096
12. Mattar S, Guzmán C, Calderón A, González M. Infecciones por arenavirus. Revista MVZ Córdoba. 2017;22(supl): 6089-6100. http://dx.doi.org/10.21897/rmvz.1078
13. Guzmán C, Calderón A, González M, Mattar S. Infecciones por hantavirus. Rev MVZ Córdoba. 2017;22(supl): 6101-17. http://dx.doi.org/10.21897/rmvz.1079
14. Calderon A, Guzman C, Salazar J, Figueiredo L, Mattar S. Viral Zoonoses That Fly with Bats: A Review. Journal of Parasite Biodiversity.2016;6:1-9. https://digitalcommons.unl.edu/manter/7
15. Hay S, Battle K, Pigott D, Smith D, Moyes C, Bhatt S et al. Global mapping of infectious disease. Philos Trans R Soc Lond B Biol Sci. 2013;368(1614):20120250. https://pubmed.ncbi.nlm.nih.gov/23382431
16. Mills J, Childs J, Ksiasek T, Peters C. Métodos para trampeo y muestreo de pequeños mamíferos para estudios virológicos [Internet]. CDC. Center for Disease Control and Prevention. Atlanta, GA; 1998. 1-65. Disponible en: https://stacks.cdc.gov/view/cdc/11583
17. Moreli M, Moro De Sousa R, Figueiredo L. Detection of Brazilian hantavirus by reverse transcription polymerase chain reaction amplification of N gene in patients with hantavirus cardiopulmonary syndrome. Mem Inst Oswaldo Cruz. 2004;99(6):633-8. https://doi.org/10.1590/s0074-02762004000600018
18. Delgado S, Erickson B, Agudo R, Blair P, Vallejo E, Albariño C, et al. Chapare virus, a newly discovered arenavirus isolated from a fatal hemorrhagic fever case in Bolivia. PLoS Pathogens. 2008;4(4):1-6. https://doi.org/10.1371/journal.ppat.1000047
19. Di Rienzo J, Casanoves F, Balzarini M, Gonzalez L, Tablada M, Robledo C. InfoStat [Internet]. versión 24. Córdoba, Argentina: Universidad Nacional de Córdoba; 2011. http://www.infostat.com.ar/
20. ICLAS. Principios rectores internacionales para investigación biomédica con animales [Internet]. 2012 p. 1. http://www.cioms.ch/index.php/12-newsflash/227-cioms-and-iclas-release-the-new-international-guiding-principles-for-biomedical-research-involving-animals
21. Murray KA, Daszak P. Human ecology in pathogenic landscapes: Two hypotheses on how land use change drives viral emergence. Curr opin virol. 2013 3(1):79-83. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713401/
22. Guzmán C, Mattar S, Calderón A. Diversidad de roedores, hantavirus y su relación con la salud pública. Salud Uninorte. 2015;31(3):554-98. https://doi.org/10.14482/SUN.31.3.567
23. Wiethoelter A, Beltrán-Alcrudo D, Kock R, Mor S. Global trends in infectious diseases at the wildlife-livestock interface. PNAS. 2015; 112(31):9662-7. https://doi.org/10.1073/pnas.1422741112
24. Vieira A, Di Azevedo M, D’Andrea P, do Val Vilela R, Lilenbaum W. Neotropical wild rodents Akodon and Oligoryzomys (Cricetidae: Sigmodontinae) as important carriers of pathogenic renal Leptospira in the Atlantic forest, in Brazil. Res Vet Sci. 2019; 124:280-3. https://doi.org/10.1016/j.rvsc.2019.04.001
25. Ernesto J, Levis S, Pini N, Polop J, Steinmann A, Provensal M. Mechanisms of Hantavirus Transmission in Oligoryzomys longicaudatus. EcoHealth. 2019; 16(4):671-81. https://pubmed.ncbi.nlm.nih.gov/31792647/
26. Fernandes J, de Oliveira R, Guterres A, Barreto-Vieira D, Terças A, Teixeira B, et al. Detection of Latino virus (Arenaviridae: Mammarenavirus) naturally infecting Calomys callidus. Acta Trop. 2018; 179:17-24. https://doi.org/10.1016/j.actatropica.2017.12.003
27. Castellar A, Guevara M, Rodas J, Londoño A, Arroyave E, Díaz F, et al. Primera evidencia de infección por el virus de la coriomeningitis linfocítica (arenavirus) en roedores Mus musculus capturados en la zona urbana del municipio de Sincelejo, Sucre, Colombia. Biomedica. 2017; 37(Supl.1):75-85. https://revistabiomedica.org/index.php/biomedica/article/view/3226
28. Montoya C, Cajimat M, Milazzo M, Diaz F, Rodas J, Valbuena G, et al. Phylogenetic Relationship of Necoclí Virus to Other South American Hantaviruses (Bunyaviridae: Hantavirus). Vector Borne Zoonotic Dis. 2015; 15(7):438-45. https://doi.org/10.1089/vbz.2014.1739
29. Mattar S, Guzman C, Arrazola J, Soto E, Barrios J, Pini N, et al. Antibody to arenaviruses in rodents, Caribbean Colombia. Emerg infect Dis. 2011; 17(7):1315-7. https://dx.doi.org/10.3201%2Feid1707.101961
30. Sánchez L, Mattar S, Rodriguez D, Tíque V, Rodriguez I. First serological evidence of hantavirus infection in humans from the Orinoquia region of Colombia. Braz J Infect Dis. 2016; 20(5):507-8. https://doi.org/10.1016/j.bjid.2016.05.006