Effects of the use of phytonutrients in the diet of dairy ruminants: Systematic review

Efectos del uso de fitonutrientes en la dieta de rumiantes lecheros: Revisión sistemática

Objective. This systematic review examines the effects of essential oils used as phytonutrients in the diet of dairy animals, considering parameters such as feed consumption, total apparent digestibility, methane emissions and milk production, based on studies published between 2018 and 2023. Material and methods. Bibliographic research electronic method resulted in a careful selection of articles, which were reviewed and tabulated for evaluation. Results. The results show that 51.35% of the articles did not report significant effects of phytonutrients on milk production. However, 66.67% of the studies observed an increase in feed efficiency and 50% reported the presence of effects on apparent digestibility. Furthermore, there was a reduction in methane emissions in animals treated with phytonutrients. Conclusions. Sharing these results with dairy farming professionals can promote more sustainable and effective practices, as well as support future research and innovations in animal nutrition, aiming for both productive efficiency and environmental sustainability.

1. Oliveira LFT, Silva SP. Mudanças Institucionais e Produção Familiar na Cadeia Produtiva do Leite no Oeste Catarinense. Revista de Economia e Sociologia Rural. 2012; 50(4):705–720. https://doi.org/10.1590/S0103-20032012000400007
2. Bertoni G, Trevisi E, Lombardelli R. Some new aspects of nutrition, health conditions and fertility of intensively reared dairy cows. Italian Journal of Animal Science. 2016; 8(4):491–518. https://doi-org.ez47.periodicos.capes.gov.br/10.4081/ijas.2009.491
3. Oh J, Wall EH, Bravo DM, Hristov AN. Host-mediated effects of phytonutrients in ruminants: A review. J Dairy Sci. 2017; 100(7):5974–5983. https://doi.org/10.3168/jds.2016-12341
4. Monteschio JO. Dietas suplementadas com óleos essenciais de cravo e alecrim e óleos protegidos (eugenol, timol e vanilina) sobre a qualidade da carne de novilhas terminada em confinamento [Tese de Doutorado]. Universidade Estadual de Maringá; 2017. http://repositorio.uem.br:8080/jspui/handle/1/4671
5. Bakkali F, Averbeck S, Averbeck D, Idaomar M. Biological effects of essential oils – A review. Food and Chemical Toxicology. 2008; 46(2):446–475. https://doi.org/10.1016/j.fct.2007.09.106
6. Ribeiro-Santos R, Andrade M, Sanches-Silva A. Application of encapsulated essential oils as antimicrobial agents in food packaging. Curr Opin Food Sci. 2017; 14:78–84. https://doi.org/10.1016/j.cofs.2017.01.012
7. Neyeloff JL, Fuchs SC, Moreira LB. Meta-analyses and Forest plots using a microsoft excel spreadsheet: Step-by-step guide focusing on descriptive data analysis. BMC Res Notes. 2012; 5(1):1–6. https://doi-org/10.1186/1756-0500-5-52
8. Mezzetti M, Premi M, Minuti A, Bani P, Lopreiato V, Trevisi E. Effect of a feed additive containing yeast cell walls, clove and coriander essential oils and Hibiscus sabdariffa administered to mid-lactating dairy cows on productive performance, rumen fluid composition and metabolic conditions. Italian Journal of Animal Science. 2021; 21(1):86–96. https://doi-org/10.1080/1828051X.2021.2019619
9. Kong F, Wang S, Dai D, Cao Z, Wang Y, Li S, Wang W. Preliminary investigation of the effects of rosemary extract supplementation on milk production and rumen fermentation in high-producing dairy cows. Antioxidants. 2022; 11(9):1715. https://doi.org/10.3390/antiox11091715
10. Al-Suwaiegh SB, Almotham AM, Alyousef YM, Mansour AT, Al-Sagheer AA. Influence of Functional Feed Supplements on the Milk Production Efficiency, Feed Utilization, Blood Metabolites, and Health of Holstein Cows during Mid-Lactation. Sustainability. 2022; 14:8444. https://doi.org/10.3390/su14148444
11. Rossi CAS, Silvia G, Dell’Anno M, Compiani R, Rossi L. Effect of a blend of essential oils, bioflavonoids and tannins on in vitro methane production and in vivo production efficiency in dairy cows. Animals. 2022; 12(6):728. https://doi.org/10.3390/ani12060728
12. Foskolos A, Ferret A, Siurana A, Castillejos L, Calsamiglia S. Effects of capsicum and propyl-propane thiosulfonate on rumen fermentation, digestion, and milk production and composition in dairy cows. Animals. 2020; 10:859. https://doi.org/10.3390/ani10050859
13. Benchaar C. Feeding oregano oil and its main component carvacrol does not affect ruminal fermentation, nutrient utilization, methane emissions, milk production, or milk fatty acid composition of dairy cows. Journal of Dairy Science. 2020; 103(2):1516-1527. https://doi.org/10.3168/jds.2019-17230
14. Elcoso G, Zweifel B, Bach A. Effects of a blend of essential oils on milk yield and feed efficiency of lactating dairy cows. Applied Animal Science 2019; 35(3):304-311. https://doi.org/10.15232/aas.2018-01825
15. Kolling GJ, Stivanin SCB, Gabbi AM, Machado FS, Ferreira AL, Campos MM, Fischer V. Performance and methane emissions in dairy cows fed oregano and green tea extracts as feed additives. Journal of Dairy Science. 2018; 101(5):4221-4234. https://doi.org/10.3168/jds.2017-13841
16. Daning DRA, Widyobroto BP, Yusiati LM, Hanim C. Effect of galangal (Alpinia galanga) essential oil supplementation on milk production, composition, and characteristics of fatty acids in dairy cows. Adv Anim Vet Sci. 2022; 10(1):192-202. http://dx.doi.org/10.17582/journal.aavs/2022/10.1.192.202
17. Al-Suwaiegh SB, Morshedy SA, Mansour AT, Ahmed MH, Zahran SM, Alnemr TM, Sallam SMA. Effect of an Essential Oil Blend on Dairy Cow Performance during Treatment and Post-Treatment Periods. Sustainability. 2020; 12(21):9123. https://doi.org/10.3390/su12219123
18. Silva RB, Pereira MN, Araujo RC, Silva WR, Pereira RAN. A blend of essential oils improved feed efficiency and affected ruminal and systemic variables of dairy cows. Translational Animal Science. 2020; 4(1):182–193. https://doi.org/10.1093/tas/txz183
19. Salem AY, El-Awady HG, El-Dein MAT, Eisa DA. Effect of supplementation of aromatic plants oils on immunity, udder health and milk production of Friesian cows. Slovenian Veterinary Research. 2019; 56(22):523-530. https://doi.org/10.26873/SVR-790-2019
20. Silva GG, Takiya CS, Del Valle TA, de Jesus EF, Grigoletto NT, Nakadonari B, Rennó FP. Nutrient digestibility, ruminal fermentation, and milk yield in dairy cows fed a blend of essential oils and amylase. Journal of Dairy Science. 2019; 101(11):9815-9826. https://doi.org/10.3168/jds.2018-14789
21. Hausmann J, Deiner C, Patra AK, Immig I, Starke A, Aschenbach JR. Effects of a combination of plant bioactive lipid compounds and biotin compared with monensin on body condition, energy metabolism and milk performance in transition dairy cows. PloS One. 2018; 13(3):e0193685. https://doi.org/10.1371/journal.pone.0193685
22. Matra M, Wanapat M. Phytonutrient pellet supplementation enhanced rumen fermentation efficiency and milk production of lactating Holstein-Friesian crossbred cows. Animal Nutrition. 2022; 9:119-126. https://doi.org/10.1016/j.aninu.2021.12.002
23. Mirzaei-Alamouti H, Namdarpour H, Abdollahi A, Amanlou H, Patra A K, Shahir M H, ... Vazirigohar M. Nutrient digestibility, blood metabolites, and production performance of peripartal ewes fed dietary plant extract and monensin. Small Ruminant Research. 2021; 202:106453. https://doi.org/10.1016/j.smallrumres.2021.106453
24. Hassan F, Tang Z, Ebeid HM, Li M, Peng K, Liang X, Yang C. Consequences of herbal mixture supplementation on milk performance, ruminal fermentation, and bacterial diversity in water buffaloes. Peer J. 2021: 9:e11241. https://doi.org/10.7717/peerj.11241
25. Kalaitsidis K, Sidiropoulou E, Tsiftsoglou O, Mourtzinos I, Moschakis T, Basdagianni Z, Vasilopoulos S, Chatzigavriel S, Lazari D, Giannenas I. Effects of cornus and its mixture with oregano and thyme essential oils on dairy sheep performance and milk, yoghurt and cheese quality under heat stress. Animals. 2021; 11(4):1063. https://doi.org/10.3390/ani11041063
26. Kholif AE, Hassan AA, Matloup OH, El A, Ghada M. Top-dressing of chelated phytogenic feed additives in the diet of lactating Friesian cows to enhance feed utilization and lactational performance. Annals of Animal Science. 2021; 21(2):657-673. https://doi.org/10.2478/aoas-2020-0086
27. Silva SNS, Chabrillat T, Kerros S, Guillaume S, Gandra JR, de Carvalho GGP, ... de Freitas Jr JE. Effects of plant extract supplementations or monensin on nutrient intake, digestibility, ruminal fermentation and metabolism in dairy cows. Animal Feed Science and Technology. 2021; 275:114886. https://doi.org/10.1016/j.anifeedsci.2021.114886
28. Dey A, Attri K, Dahiya S S, Paul S S. Influence of dietary phytogenic feed additives on lactation performance, methane emissions and health status of M urrah buffaloes (Bubalus bubalis). Journal of the Science of Food and Agriculture. 2021; 101(10):4390-4397. https://doi.org/10.1002/jsfa.11080
29. Benchaar C. Diet supplementation with thyme oil and its main component thymol failed to favorably alter rumen fermentation, improve nutrient utilization, or enhance milk production in dairy cows. Journal of Dairy Science. 2021; 104(1):324-336. https://doi.org/10.3168/jds.2020-18401
30. Boushehri M, Sadeghi AA, Chamani M, Aminafshar M. Effects of antioxidants and prebiotics as vegetable pellet feed on production performance, hematological parameters and colostrum immunoglobulin content in transition dairy cows. Italian Journal of Animal Science. 2021; 20(1):1863–1869. https://doi.org/10.1080/1828051X.2021.1987158
31. El-Essawy AM, Anele UY, Abdel-Wahed AM, Abdou AR, Khatta IM. Effects of anise, clove and thyme essential oils supplementation on rumen fermentation, blood metabolites, milk yield and milk composition in lactating goats. Animal Feed Science and Technology. 2021; 271:114760. https://doi.org/10.1016/j.anifeedsci.2020.114760
32. Carrazco AV, Carlyn BP, Yongjing ZYP, John JM, Edward JD, Frank MM. The impact of essential oil feed supplementation on enteric gas emissions and production parameters from dairy cattle. Sustainability. 2020; 12(24):10347. https://doi.org/10.3390/su122410347
33. Khattab MSA, Kholif AE, Abd El Tawab AM, Shaaban MM, Hadhoud FI, El-Fouly HA, Olafadehan OA. Effect of replacement of antibiotics with thyme and celery seed mixture on the feed intake and digestion, ruminal fermentation, blood chemistry, and milk lactation of lactating Barki ewes. Food & Function. 2020; 11(8):6889-6898. https://doi.org/10.1039/D0FO00807A
34. Attri K, Dey A, Dahiya SS, Paul SS, Jerome A, Bharadwaj A, Kakker NK. Abatement of enteric methane production from lactating Murrah buffaloes (Bubalus bubalis) with improving production performance and immune status through dietary supplementation of composite feed additive. Environ Sci Pollut Res. 2020; 27:22476–22485. https://doi.org/10.1007/s11356-020-08601-x
35. Kholif AE, Hassan AA, El Ashry GM, Bakr MH, El-Zaiat HM, Olafadehan OA, … Sallam SMA. Phytogenic feed additives mixture enhances the lactational performance, feed utilization and ruminal fermentation of Friesian cows. Animal Biotechnology. 2020; 32(6):708–718. https://doi.org/10.1080/10495398.2020.1746322
36. Grazziotin RCB, Halfen J, Rosa F, Schmitt E, Anderson JL, Ballard V, Osorio JS. Altered rumen fermentation patterns in lactating dairy cows supplemented with phytochemicals improve milk production and efficiency. Journal of Dairy Science. 2020; 103(1):301-312. https://doi.org/10.3168/jds.2019-16996
37. Stivanin SCB, Vizzotto EF, de Paris M, Zanela MB, Passos LT, Angelo IDV, Fischer V. Addition of oregano or green tea extracts into the diet for Jersey cows in transition period. Feeding and social behavior, intake and health status. Plant extracts for cows in the transition period. Animal Feed Science and Technology. 2019; 257:114265. https://doi.org/10.1016/j.anifeedsci.2019.114265
38. Oh J, Harper M, Hristov AN. Effects of lowering crude protein supply alone or in a combination with essential oils on productivity, rumen function and nutrient utilization in dairy cows. Animal. 2019; 13(11):2510-2518. https://doi.org/10.1017/S1751731119001083
39. Joch M, Kudrna V, Hakl J, Božik M, Homolka P, Illek J, Výborná A. In vitro and in vivo potential of a blend of essential oil compounds to improve rumen fermentation and performance of dairy cows. Animal Feed Science and Technology. 2019; 251:176-186. https://doi.org/10.1016/j.anifeedsci.2019.03.009
40. Olijhoek DW, Hellwing ALF, Grevsen K, Haveman LS, Chowdhury MR, Løvendahl P, Lund P. Effect of dried oregano (Origanum vulgare L.) plant material in feed on methane production, rumen fermentation, nutrient digestibility, and milk fatty acid composition in dairy cows. Journal of Dairy Science. 2019; 102(11):9902-9918. https://doi.org/10.3168/jds.2019-16329
41. Oh J, Harper M, Lang CH, Wall EH, Hristov AN. Effects of phytonutrients alone or in combination with monensin on productivity in lactating dairy cows. Journal of Dairy Science. 2018; 101(8):7190-7198. https://doi.org/10.3168/jds.2018-14439
42. Kholif AE, Kassab AY, Azzaz HH, Matloup OH, Hamdon HA, Olafadehan OA, Morsy TA. Essential oils blend with a newly developed enzyme cocktail works synergistically to enhance feed utilization and milk production of Farafra ewes in the subtropics. Small Ruminant Research. 2018; 161:43-50. https://doi.org/10.1016/j.smallrumres.2018.02.011
43. Braun HS, Schrapers KT, Mahlkow-Nerge K, Stumpff F, Rosendahl J. Dietary supplementation of essential oils in dairy cows: evidence for stimulatory effects on nutrient absorption. Animal. 2019; 13(3):518-523. https://doi.org/10.1017/S1751731118001696
44. Regnault-Roger C, Vincent C, Arnason JT. Essential Oils in Insect Control: Low-Risk Products in a High-Stakes World. Annual Review of Entomology. 2011; 57:405-424. https://doi.org/10.1146/annurev-ento-120710-100554
45. Akthar MS, Degaga B, Azam T. Antimicrobial activity of essential oils extracted from medicinal plants against the pathogenic microorganisms: A review. Issues in Biological Sciences and Pharmaceutical Research. 2014; 2(1):001–007. https://journalissues.org/ibspr/abstract/akthar-et-al/
46. Beauchemin KA, Krehbiel CR, Newbold CJ. Chapter 7 Enzymes, bacterial direct-fed microbials and yeast: principles for use in ruminant nutrition. Biology of Growing Animals. 2006; 4:251–284. https://doi.org/10.1016/S1877-1823(09)70094-3
47. Calsamiglia S, Busquet M, Cardozo PW, Castillejos L, Ferret A. Invited review: Essential oils as modifiers of rumen microbial fermentation. J Dairy Sci. 2007; 90(6):2580–2595. http://dx.doi.org/10.3168/jds.2006-644
48. Chami N, Bennis S, Chami F, Aboussekhra A, Remmal A. Study of anticandidal activity of carvacrol and eugenol in vitro and in vivo. Oral Microbiol Immunol. 2005; 20:106–111. https://doi.org/10.1111/j.1399-302X.2004.00202.x
49. Stefanakis MK, Touloupakis E, Anastasopoulos E, Ghanotakis D, Katerinopoulos HE, Makridis P. Antibacterial activity of essential oils from plants of the genus Origanum. Food Control. 2013; 34(2):539–546. http://dx.doi.org/10.1016/j.foodcont.2013.05.024
50. Silvestre T, Räisänen SE, Cueva SF, Wasson DE, Lage CFA, Martins LF, et al. Effects of a combination of Capsicum oleoresin and clove essential oil on metabolic status, lactational performance, and enteric methane emissions in dairy cows. J Dairy Sci. 2022; 105(12):9610–9622. https://doi.org/10.3168/jds.2022-22203
51. Ferret A, Plaixats J, Caja G, Gasa J, Prió P. Using markers to estimate apparent dry matter digestibility, faecal output and dry matter intake in dairy ewes fed Italian ryegrass hay or alfalfa hay. Small Ruminant Research. 1999; 33(2):145–152. https://doi.org/10.1016/S0921-4488(99)00015-2