Aglepristone efficiency with and without the canine pyometra cloprostenol

Aglepristone efficiency with and without the canine pyometra cloprostenol

ABSTRACT

Objective. Evaluate the effectiveness of aglepristone with and without cloprostenol for treating canine pyometra. Materials and methods. Ten female French Bulldogs between 3-8 years of age diagnosed with pyometra were divided into two groups, one receiving a 10 mg/kg dose of aglepristone subcutaneously on days 1, 2, 8, 14 and 28, and the other an equal dose on days 1, 3, 8 and 15, as well as a 1 μg/kg dose of cloprostenol subcutaneously on days 3 and 8. Both groups received 5 mg/kg of enrofloxacin orally every 12 hours for 28 days. Hematic profiles were generated on days 1 and 28 and counted days until the next heat, expelling purulent material and of clinical recuperation. Results. There was no statistical difference in the variables of the line red blood cells between times and protocols. The line of white blood cells showed a statistical difference between days of treatment but not between the two groups. Both treatments were effective resulting in complete clinical recuperation. The combination of aglepristone with cloprostenol acted more quickly, decreasing the number of days of secretion, abdominal pain, and the recuperation of normal activity and appetite. All 10 females were bred during their first heat. Three females from the aglepristone group and one from the combined aglepristone with cloprostenol group were impregnated. Conclusions. Both protocols, combined with enrofloxacin, produced complete clinical recuperation in bitches with pyometra, but it was achieved more rapidly when given the combination of both aglepristone and cloprostenol.

RESUMEN

Objetivo. Evaluar la efectividad del aglepristone con y sin el cloprostenol en el tratamiento del piómetra canino. Materiales y métodos. Diez hembras Bulldog Francés entre 3–8 años de edad con diagnóstico de piómetra, se dividieron en dos grupos, uno recibió aglepristone a la dosis de 10 mg/kg subcutáneo los días 1, 2, 8, 14 y 28, y otro una dosis igual los días 1, 3, 8 y 15, más cloprostenol a dosis de 1 μg/kg subcutáneo los días 3 y 8. Ambos grupos recibieron enrofloxacina 5 mg/kg oral cada 12 horas por 28 días. Se realizaron perfiles hemáticos los días 1 y 28, y se valoraron días de retorno al celo, expulsión del material purulento y de recuperación clínica. Resultados. No hubo diferencia estadística en las variables de la línea roja sanguínea entre tiempos y protocolos. La línea de glóbulos blancos mostró diferencia estadística entre los días de tratamiento pero no entre los dos grupos. Ambos tratamientos fueron eficaces en la recuperación clínica completa, siendo el aglepristone más cloprostenol más rápido en disminuir los días de secreción, dolor abdominal, recuperación de la actividad normal y apetito. Las 10 hembras fueron servidas en el primer celo y quedaron preñadas tres hembras del grupo del aglepristone y una del grupo aglepristone con cloprostenol respectivamente. Conclusiones. Ambos protocolos combinados con enrofloxacina, produjeron la recuperación clínica completa en perras con piómetra, pero se consiguió más rápidamente en el grupo de aglepristone con cloprostenol.

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