Hepatic biochemical profile in guinea pigs fed with inclusion of pisonay (Erythrina edulis) meal

Perfil bioquímico hepático en cuyes alimentados con la inclusión de harina de pisonay (Erythrina edulis)

Objective. Evaluate the effect of the percentage of inclusion and regrowth age of Erythrina edulis leaf meal on the response of hepatic metabolites of guinea pigs in the inter-Andean valley of Abancay. Materials and methods. 10 improved male guinea pigs assigned to each experimental diet containing 10, 20 and 30% inclusion by 4, 8 and 12 months of regrowth age and a control diet with 20% alfalfa meal were used. At 56 days, blood samples were collected in order to determine hepatic metabolites: total protein, albumin, total bilirubin, aminotransferases, alkaline phosphatase, and gamma-glutamyl transpeptidase. Results. Serum levels of albumin, total bilirubin, aminotransferases and gamma-glutamyl transpeptidase were different from the control diet (p<0.05). Total protein and albumin (6.0 and 3.0 mg/dl) were higher at 12 months compared to eight (5.8 and 2.8 mg/dl) and four (5.6 and 2.8 mg/dl) months of regrowth age; total bilirubin (0.2 mg/dl) decreased to 0.1 mg/dl with increasing age at regrowth (p<0.05). Alanine and aspartate aminotransferase decreased due to the effect of regrowth age (54.0 to 34.5 IU/L; 80.7 to 56.9 IU/L, respectively) and inclusion percentage (46.7 to 35.8 IU/L; 75.5 to 57.7 IU/L, respectively) (p<0.05). Total bilirubin decreased from 0.2 to 0.1 mg/dl as the percentage of inclusion increased (p<0.05). Conclusions. Liver metabolites of guinea pigs showed variability in total bilirubin and aminotransferases due to the inclusion and regrowth age of pisonay meal.

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